Donor pre-treatment with tacrolimus reduces transplant vasculopathy

Susa, Denis; Engel, Sandra van de; Damme, Luc C.A. van; Roest, Henk P.; Krams, Rob; IJzermans, Jan N.M.; Bruin, Ron W. F. de

doi:10.1016/j.phrs.2008.12.006

Cited by 2 publications

(1 citation statement)

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“…Susa et al observed a significantly reduced MMP-2/ MMP-9 activity after tacrolimus treatment in a rat model. 21 Future research on this topic with molecular testing, for example, is necessary to decode the correlation between collagen metabolism and immunosuppressive treatment in hernia patients.…”

Section: Discussionmentioning

confidence: 99%

Incisional Hernia After Liver Transplantation: Analysis of Tailored Open Mesh Repair

Heise

Kroh

Eickhoff

et al. 2019

International Surgery

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Objective Incisional hernia is a frequent complication post liver transplantation (LT). The aim of this study was to compare divergent approaches to open abdominal wall repair post-LT. Summary of background data After liver transplantation (LT) via Mercedes incision (MSI) we observed an incidence of incisional hernia between 5% and 34%. Conventional repair consists of reopening the whole incision and reinforcement of the whole fascia using a mesh plastic in sublay position. This retrospective analysis compares open mesh repair with complete reinforcement of the Mercedes incision and open mesh repair of solely the abdominal wall defect. Methods Between 2010 and 2015, 218 orthotopic liver transplantations (LT) were performed at our institution, and 25 (11.5%) of those patients required an incisional hernia repair post-LT. One group received a local hernia repair (n = 15) while the other group obtained a reconstruction of the whole MSI (n = 10). We analyzed the preoperative status, causative factors for incisional hernia, operative details, and long-term outcome of these patients. Results Analyzing preoperative details no significant differences were found between the 2 groups. The mean time post-LT at which the abdominal wall defect appeared was 18 ± 12 months. The mean follow-up time after abdominal wall repair was 15 (11–19) months. Additionally, 1 (4%) patient developed a hernia recurrence without statistic significant difference between the 2 groups (P = 0.400). Conclusion Local mesh reinforcement seems to be feasible and safe in incisional hernia patients after Mercedes incision due to liver transplantation.

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Section: Discussionmentioning

confidence: 99%