Donor genetic burden for cerebrovascular risk and kidney transplant outcome
Kane E. Collins,
Edmund Gilbert,
Vincent Mauduit
et al.
Abstract:Background and hypothesis
Kidney grafts from donors who died of stroke and related traits have worse outcomes relative to grafts from both living donors and those who died of other causes. We hypothesise that deceased donors, particularly those who died of stroke, have elevated polygenic burden for cerebrovascular traits. We further hypothesise that this donor polygenic burden is associated with inferior graft outcomes in the recipient.
Methods
Using a dat… Show more
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