Donor-Derived Neuroendocrine Carcinoma Transmission to Two Kidney Transplant Recipients Demonstrated by Short Tandem Repeat Analysis: A Case Report

Takeda, Kotaro; Mittenzwei, Rhonda; Geisinger, Kim R.; Datto, Michael B.; Rebellato, Lorita M.

doi:10.1016/j.transproceed.2021.03.002

Cited by 1 publication

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“…The short tandem repeat (STR) locus is composed of short, repetitive sequence elements throughout the genomes of a wide range of species [ 1 , 2 ]. Genotyping of highly polymorphic STR is not only widely used for individual genetic identification in paternity disputes, family relationship testing, and forensic DNA analysis but also for monitoring chimerism after hematopoietic stem cell transplantation (HSCT).…”

Section: Introductionmentioning

confidence: 99%

A Case of Type 1 Triallelic Patterns at D5S818, D18S51, D6S1043, and FGA Demonstrated by Short Tandem Repeat Analysis

Fan

Zhang

Zheng³

et al. 2022

International Journal of Clinical Practice

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The triallelic pattern of short tandem repeat (STR) is rare; especially, the case where this pattern exists at 4 loci has not been reported. Here, we report the type 1 triallelic patterns at D5S818, D18S51, D6S1043, and FGA from a Chinese family, which were observed during our routine chimerism assays. Before hematopoietic stem cell transplantation, the blood sample of the certain patient was analyzed by performing chimerism analysis. A preliminary STR analysis was also performed on the samples of the patient’s parents. STR signal data illustrated that the sum of the peak chart areas of the two types inherited from the father was basically the same as that of the mother, belonging to the type 1 triallelic pattern. In addition, the patient’s elder sister’s STR result appeared to be normal. Altogether, we presented a pedigree, in which the triallelic pattern was linked by inheritance in the family. This is the first reported case of the triallelic pattern at D5S818, D18S51, D6S1043, and FGA all around the world. We hope that in the future there will be any tools to achieve accurate verification against this possibility.

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Section: Introductionmentioning

confidence: 99%