Donor-derived cell-free DNA predicted allograft rejection and severe microvascular inflammation in kidney transplant recipients
Hyung Duk Kim,
Hyunjoo Bae,
Hyunhye Kang
et al.
Abstract:IntroductionThe aim of this study is to investigate the clinical validity of donor-derived cell-free DNA (dd-cfDNA) in comparison with that of donor specific anti-HLA antibody (DSA) for predicting biopsy-proven rejection (BPR)and severe microvascular inflammation (severe MVI) in kidney transplant recipients (KTRs).MethodsIn this prospective observational investigation, 64 KTRs who underwent the indicated biopsies were included. Blood samples collected prior to biopsy were tested for dd-cfDNA and DSA. Biopsy sp… Show more
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