Abstract:Two π-extended bay-bridged tribenzotriquinacenes ("TBTQ wizard hats") 12 and 16 bearing three mutually conjugated, alternating veratrole-type and ortho-benzoquinone units were synthesized. The electronic properties of these complementarily arranged, nonplanar push-pull systems are affected by the fusion with the rigid, C 3 -symmetric TBTQ core to a different extent, as revealed by X-ray structural analysis, UV-vis spectroscopy and cyclovoltammetry. The combination of three quinone units within the original TBT… Show more
“…1B and C ), with circa 90° angle between its fused indanes, 16 host MTX with the aromatics folded at ∼90° in aqueous media? First, the electron-rich surface 17 of the TBTQ moiety of 1 6+ ( Fig. 1C ) is expected to complement the electron-deficient pteridine from MTX.…”
We describe the preparation and study of novel cavitands, molecular bowls 16+ and 26+, as good binders of the anticancer drug methotrexate (MTX). Molecular bowls are comprised of a curved...
“…1B and C ), with circa 90° angle between its fused indanes, 16 host MTX with the aromatics folded at ∼90° in aqueous media? First, the electron-rich surface 17 of the TBTQ moiety of 1 6+ ( Fig. 1C ) is expected to complement the electron-deficient pteridine from MTX.…”
We describe the preparation and study of novel cavitands, molecular bowls 16+ and 26+, as good binders of the anticancer drug methotrexate (MTX). Molecular bowls are comprised of a curved...
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