Donor‐Acceptor Substituted 2‐Phenylpyridines by Means of Reductive C,C–Cross Coupling Reaction

Abstract

The preparation of 2‐phenylpyridines decorated with an electron donating and accepting unit, which are potentially suitable to induce second harmonic generation, was performed by means of reductive nickel catalyzed C,C‐cross coupling reaction, developed by Gosmini et. al. We were successful to obtain the desired 2‐phenylpyridines directly from donor‐functionalized arylhalides and acceptor‐modified 2‐halopyridines with a cheap and easy to prepare Ni catalyst. It turned out that even the presence of hydroxy groups and carboxylic acids are tolerated in this reaction, whereas in the case of a formyl group containing pyridine substrate no C,C‐coupled product was obtained. However, the coupling was successful when the formyl function was protected by an acetal formation.