Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window

Wei, Zuwu; Xin, Fuli; Zhang, Jian; Wu, Ming; Qiu, Ting; Lan, Yintao; Qiao, Shuangying; Liu, Xiaolong; Liu, Jingfeng

doi:10.1039/c9cc07821e

Cited by 71 publications

(67 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PD-FA nanoparticles displayed a broad absorption spectrum from the visible to NIR region. This indicated that for two characteristic peaks, at 450 nm and 845 nm, the former is mainly due to π-π* transition of the polymer backbone, 54 while the latter is ascribed to the optical absorption of PD-FA 2884 nanoparticles in NIR. With the broadband absorption spectrum, the PD-FA nanoparticles can satisfy different demands according to various requirements.…”

Section: Synthesis and Characterization Of The Pd-fa Nanoparticlesmentioning

confidence: 99%

In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles

Qiu¹,

Lan²,

Wei³

et al. 2021

IJN

Self Cite

View full text Add to dashboard Cite

Background: Effective treatment strategy for cervical carcinoma is subject to the limitation of its anatomical location and histological characteristics. Comprehensive imaging before cervical carcinoma treatment is of great significance for the patients. Current imaging methods cannot meet the requirements of high resolution, deep imaging depth and noninvasive imaging at the same time. Fortunately, Photoacoustic imaging (PAI) is a novel imaging method that combines rich optical contrast, high ultrasonic spatial resolution, and deep penetration depth in a single modality. Moreover, PAI-guided photothermal therapy (PTT) by aid of targeting nanoparticles is an emerging and effective cancer treatment in recent years. Methods: Here, strong near-infrared region (NIR) absorption-conjugated polymer PIIGDTS (PD) nanoparticles with folic acid (FA) modification (namely, PD-FA) that targeted at Hela cell were specifically designed as cervical tumor imaging contrast agents and photothermal agents. Results: The obtained PD-FA nanoparticles exhibited admirable photoacoustic contrastenhancing ability and desirable PTT behavior with the photothermal conversion efficiency as high as 62.6% in vitro. Furthermore, the PAI performance and PTT efficiency were tested in HeLa tumor-bearing nude mice after injection of PD-FA nanoparticles. In vivo multiscale, PAI provided B-san and 3D dimension imaging for intuitive and comprehensive information of Hela tumor. Moreover, the Hela tumor can be completely eliminated within 18 days after PTT, with no toxicity and side effects. Conclusion:In summary, PD-FA injection combined with PAI and PTT systems provides a novel powerful tool for early diagnosis and precise treatment of cervical cancer.

show abstract

Section: Synthesis and Characterization Of The Pd-fa Nanoparticlesmentioning

confidence: 99%

In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles

Qiu¹,

Lan²,

Wei³

et al. 2021

IJN

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, a co ‐benzobisthiadiazole‐dithienosilole SP (SP34) with a maximum absorption peak at about 1090 nm was designed. [ 58 ] SP34 was coprecipitated with DSPE‐PEG to yield water‐soluble SPN34. The obtained SPN34 exhibited a superior photothermal conversion efficiency of 65% under NIR‐II laser irradiation and thus showed the powerful apoptosis/necrosis‐inducing ability for both in vitro and in vivo experiments.…”

Section: Nir‐ii Photothermal Therapymentioning

confidence: 99%

Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Zhen

Jiang

2021

Small

194

129

View full text Add to dashboard Cite

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis and treatment. Although many exogenous contrast agents have been developed for PA imaging and PTT, the design guidelines to amplify their imaging and therapy performances remain challenging and are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π‐electron delocalized backbones can be designed to amplify their PA imaging and PTT performance, because of their clear structure–property relation and versatility in modifying their molecular structures to tune their photophysical properties. This review summarizes the recent advances in the photoacoustic imaging and photothermal therapy applications of semiconducting polymer nanoparticles with a focus on signal amplification and second near‐infrared (NIR‐II, 1000–1700 nm) construction. The strategies such as structure–property screening, fluorescence quenching, accelerated heat dissipation, and size‐dependent heat dissipation are first discussed to amplify the PA brightness of SPNs for in vivo PA. The molecular approaches to shifting the absorption of SPNs for NIR‐II PA imaging and PTT are then introduced so as to improve the tissue penetration depth for diagnosis and therapy. At last, current challenges and perspectives of SPNs in the field of imaging and therapy are discussed.

show abstract

“…The polymer nanoparticles effectively inhibited or completely eradicate the liver tumors. Wei et al prepared a new type of narrow bandgap conjugated polymer-based near-infrared diagnostic nanoparticles with a photothermal conversion efficiency as high as 65% ( Wei et al, 2020 ). The obtained NPs PBBTDTS -Aptamer nanoparticles (BDA NPs) showed good ability to target to and accumulate in human liver cancer cells in vivo .…”

Section: Photothermal Treatmentmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

show abstract

Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window

Abstract: BDA nanoparticles exhibit excellent theranostic properties including an extremely high cancer cell killing ability, admirable tumor elimination efficiency (100%) and a remarkable photoacoustic imaging contrast enhancing ability.

Cited by 71 publications

References 25 publications

In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles

In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles

Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Recent Progress on NIR-II Photothermal Therapy

Contact Info

Product

Resources

About