Donepezil Overdose

Abstract

CapitationSir: William M. Glazer says that "capitation should bring an end to reviewers as we have known them" (Supplement 2).

Evaluation of Centrally Acting Cholinesterase Inhibitor Exposures in Adults

“…Los pacientes recibieron por lo menos un tipo de terapia en 47% de las exposiciones. Estas incluyeron fluidos intravenosos (111), antieméticos (48), atropina (17), benzodiazepinas (15), oxígeno (14), antihipertensivos (4), pralidoxima (4), entubación (3), antihistamínicos (2), antiarrítmicos (1), anticonvulsivos (1), y marcapasos (1). RÉSULTATS: La recherche a permis d'identifier 1026 cas.…”

“…La plupart des expositions (65%) ont été attribuées à une erreur thérapeutique non intentionnelle. Dans 47% des cas les thérapies suivantes ont été administrées: solutions IV (111), anti-nauséeux (48), atropine (17), benzodiazépine (15), oxygène (14), antihypertenseurs (4), pralidoxime (4), intubation (3), antihistaminique (2), antiarythmisant (1), anticonvulsivant (1), et stimulateur cardiaque (1). CONCLUSIONS: La majorité des patients exposés démontrent peu ou pas d'effets indésirables.…”

Donepezil distribution in postmortem cases and potential for redistribution

“…Green et al reported that a 74-year-old woman who had accidentally taken 45 mg DPZ and presented with vomiting, drowsiness, flushing, and diarrhea. She recovered following medical treatment [19]. Similarly, Shepherd et al reported that a 79-year-old woman accidentally consumed 50 mg DPZ and presented with vomiting, drowsiness, and sinus bradycardia.…”

Assessment and Management of Toxidromes in the Critical Care Unit

“…A not uncommon scenario of milder toxicity (but presenting with delirium) is accidental self-poisoning by a patient with dementia who takes repeat doses of a cognitive-enhancing drug due to forgetfulness about medication adherence. 19 It is also possible to develop toxic cholinergic "rebound" after abrupt cessation of excessive misuse of medications with anticholinergic properties (eg, diphenhydramine, quetiapine). 20 manifestations are not significant) and, in some cases of severe toxicity, the cholinesterase regenerator pralidoxime.…”