Donation and transplantation activity in the UK during the COVID-19 lockdown

Manara, Alex; Mumford, Lisa; Callaghan, Chris; Ravanan, Rommel; Gardiner, Dale

doi:10.1016/s0140-6736(20)31692-5

Cited by 45 publications

(53 citation statements)

References 2 publications

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“…The pandemic severely affected the transplant programme in France, as elsewhere [7][8][9][10][11]. Between March 1 and July 31, the number of potential deceased organ donors fell by 16% over the same period in 2018-19 ( Fig.…”

mentioning

confidence: 99%

Impact of coronavirus disease 2019 on organ donation and transplantation in France

et al. 2020

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mentioning

confidence: 99%

Impact of coronavirus disease 2019 on organ donation and transplantation in France

et al. 2020

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“…As kidney transplantation rates declined, so did organ procurement rates. The UK reported a 39% decrease in referrals of organs to OPOs [14]. France reported a 16% decrease in all deceased organ procurement rates as compared to previous years [10].…”

Section: Donor Supplymentioning

confidence: 99%

“…Italy reported a 25% decrease in transplantation rates with living kidney transplants being particularly affected [20]. In the UK, kidney transplantation rates were down by 68% [14], and France experienced a very significant > 90% decline in kidney transplantation rates [19]. By October 2020, Australia had observed a 27% decrease in transplantation rates as compared to 2019 [21].…”

Section: Transplantation Ratesmentioning

confidence: 99%

The impact of COVID‐19 on kidney transplantation and the kidney transplant recipient – One year into the pandemic

et al. 2021

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Summary The COVID‐19 pandemic has significantly changed the landscape of kidney transplantation in the United States and worldwide. In addition to adversely impacting allograft and patient survival in postkidney transplant recipients, the current pandemic has affected all aspects of transplant care, including transplant referrals and listing, organ donation rates, organ procurement and shipping, and waitlist mortality. Critical decisions were made during this period by transplant centers and individual transplant physicians taking into consideration patient safety and resource utilization. As countries have begun administering the COVID vaccines, new and important considerations pertinent to our transplant population have arisen. This comprehensive review focuses on the impact of COVID‐19 on kidney transplantation rates, mortality, policy decisions, and the clinical management of transplanted patients infected with COVID‐19.

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“…During the COVID era, the waiting list was restricted to patients with matchability scores of ≥8, 20 was a 0 HLA-DR plus 2 HLA-B mismatch or a 1 HLA-DR plus 1 HLA-B mismatch; and level 4 was a 2 HLA-DR mismatch or a 1 HLA-DR plus 2 HLA-B mismatch. 21 A kidney donor was defined as a donor who donated at least one kidney that was transplanted.…”

Section: Cambridge Protocolmentioning

confidence: 99%

Renal transplantation during the SARS‐CoV‐2 pandemic in the UK: Experience from a large‐volume center

Georgiades

Summers

Butler

et al. 2020

Clinical Transplantation

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There is uncertainty about the safety of kidney transplantation during the SARS‐CoV‐2 pandemic due to the risk of donor transmission, nosocomial infection and immunosuppression use. We describe organ donation and transplant practice in the UK and assess whether kidney transplantation conferred a substantial risk of harm. Data from the UK transplant registry were used to describe kidney donation and transplant activity in the UK, and a detailed analysis of short‐term, single‐center, patient results in two periods: during the pre‐pandemic era from 30th December 2019 to 8th March 2020 (“Pre‐COVID era”) and the 9th March 2020 to 19th May 2020 (“COVID era”). Donor and recipient numbers fell by more than half in the COVID compared to the pre‐COVID era in the UK, but there were more kidney transplants performed in our center (42 vs. 29 COVID vs. pre‐COVID respectively). Overall outcomes, including re‐operation, delayed graft function, primary non‐function, acute rejection, length of stay and graft survival were similar between COVID and pre‐COVID era. 6/71 patients became infected with SARS‐CoV‐2 but all were discharged without critical care requirement. Transplant outcomes have remained similar within the COVID period and no serious sequelae of SARS‐CoV‐2 infection were observed in the peri‐transplant period.

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Donation and transplantation activity in the UK during the COVID-19 lockdown

Abstract: O'Dowd A. Covid-19: Johnson is on back foot over next steps to control pandemic. BMJ 2020; 369: m2152.

Cited by 45 publications

References 2 publications

Impact of coronavirus disease 2019 on organ donation and transplantation in France

Impact of coronavirus disease 2019 on organ donation and transplantation in France

The impact of COVID‐19 on kidney transplantation and the kidney transplant recipient – One year into the pandemic

Renal transplantation during the SARS‐CoV‐2 pandemic in the UK: Experience from a large‐volume center

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