Don’t forget ototoxicity during the SARS-CoV-2 (Covid-19) pandemic!

Ciorba, Andrea; Corazzi, Virginia; Skarżyński, Piotr H.; Skarżyńska, Magdalena Beata; Bianchini, Chiara; Pelucchi, Stefano; Hatzopoulos, Stavros

doi:10.1177/2058738420941754

Cited by 26 publications

(24 citation statements)

References 12 publications

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“…A change in hearing status has been reported by 1 in 10 COVID-19 adults after discharge from one hospital in Manchester in the UK (25) highlighting the need for further monitoring. This is particularly important for those who may have been treated with ototoxic medications (26).…”

Section: Discussionmentioning

confidence: 99%

Changes in Tinnitus Experiences During the COVID-19 Pandemic

Beukes

Baguley

Jacquemin

et al. 2020

Front. Public Health

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Introduction: The COVID-19 pandemic has disrupted delivery of healthcare, economic activity, and affected social interactions. Identifying and supporting those most affected by the pandemic is required. The purpose of this study was to determine the impact of the pandemic on individuals with tinnitus and to identify mediating factors. Methods: This is a mixed-methods exploratory cross-sectional study, using data collected via an online survey from 3,103 individuals with tinnitus from 48 countries. The greatest representation was from North America (49%) and Europe (47%) and other countries were only marginally represented. Results: Although the study was aimed at those with pre-existing tinnitus, 7 individuals reported having COVID-19 initiated tinnitus. Having COVID-19 symptoms exacerbated tinnitus in 40% of respondents, made no change in 54%, and improved tinnitus in 6%. Other mediating factors such as the social and emotional consequences of the pandemic made pre-existing tinnitus more bothersome for 32% of the respondents, particularly for females and younger adults, better for 1%, and caused no change to tinnitus for 67%. Pre-existing tinnitus was significantly exacerbated for those self-isolating, experiencing loneliness, sleeping poorly, and with reduced levels of exercise. Increased depression, anxiety, irritability, and financial worries further significantly contributed to tinnitus being more bothersome during the pandemic period. Conclusions: These findings have implications for tinnitus management, because they highlight the diverse response both internal and external factors have on tinnitus levels. Clinical services should be mindful that tinnitus may be caused by contracting COVID-19 and pre-existing tinnitus may be exacerbated, although in the majority of respondents Beukes et al. Tinnitus Experiences During COVID-19 there was no change. Additional support should be offered where tinnitus severity has increased due to the health, social, and/or emotional effects of the COVID-19 pandemic. Tinnitus may be more bothersome for those experiencing loneliness, having fewer social interactions, and who are more anxious or worried.

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Section: Discussionmentioning

confidence: 99%

Changes in Tinnitus Experiences During the COVID-19 Pandemic

Beukes

Baguley

Jacquemin

et al. 2020

Front. Public Health

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“…Patients affected by COVID-19 often receive medication with potential ototoxic effects. 26 The administration of hydroxychloroquine especially is a discussion topic, because of its wide offlabel use in the early times of the pandemic. The subset of neural, retinal and audio-vestibular adverse manifestations caused by quinine and derivatives, including hydroxychloroquine, are well known since the 18th century with the name of 'cinchonism'.…”

Section: Ototoxicity Of Covid-19 Treatmentsmentioning

confidence: 99%

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Fancello

Hatzopoulos

Corazzi

et al. 2021

Int J Immunopathol Pharmacol

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To describe the audio-vestibular disorders related to the newly SARS-CoV-2 infection, including the possible ototoxicity side-effects related to the use of drugs included in the SARS-CoV-2 treatment protocols. A systematic review was performed according to the PRISMA protocol. The Medline and Embase databases were searched from March 1, 2020 to April 9, 2021. Initially the search yielded 400 manuscripts, which were reduced to 15, upon the application of inclusion criteria. Sensorineural hearing loss (SNHL) is the most frequent audio-vestibular symptom described, occurring alone or in association with tinnitus and vertigo. The etiopathogenesis of the inner ear disorders related to COVID-19 infection is still poorly understood. The number of reports of COVID-19 infections associated to audio-vestibular disorders is increasing; even if the quality of the studies available is often insufficient, audio-vestibular disorders should be considered as possible manifestations to be included among the symptoms of this infection.

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“…It has been reported that the use of high-dose hydroxychloroquine may lead to both reversible or permanent deafness [ 19 ]. Likewise, favipiravir, which has also been used to treat COVID-19 patients, is considered a potentially ototoxic drug in the literature [ 20 – 22 ].…”

Section: Discussionmentioning

confidence: 99%

Mild and moderate COVID-19 disease does not affect hearing function permanently: a cross-sectional study ınvolving young and middle-aged healthcare givers

Kökoğlu

Tektaş

Baktir-Okcesiz

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose To assess the hearing function of patients with mild and moderate COVID-19. Methods The hospital staffs recovered from COVID-19 were included. The candidates who had an ear disease or progressive hearing loss prior to COVID-19, or having been hospitalised because of severe and critical COVID-19 were excluded. The age, sex, symptoms during COVID-19, and medications received for the disease were noted. The hearing thresholds (HT) of the participants who had an audiogram before having COVID-19 disease were recorded. A pure tone audiometry was conducted to all. The participants were classified into two groups; Group 1: participants who had an audiogram previously, Group 2: participants who didn’t have an audiogram previously. The changes of the HTs of the participants in Group 1 were analyzed. The HTs of the participants in Group 2 were documented without any comparison. The HTs of all participants were also analyzed by classifying them into subgroups according to their symptoms during, and medications received for COVID-19. Results Fifty-four males and 47 females (18–59 years) were included. The participants’ HTs in Group 1 ( n = 31) did not change significantly at any of the frequencies after having COVID-19 ( p > 0.05). The pure tone averages of the participants in Group 2 ( n = 70) were below 25 dB and none of the participants reported worsening of their hearing permanently. The differences between the HTs of none of the subgroups were statistically significant ( p > 0.05, p > 0.05). Conclusions Mild and moderate COVID-19 and its treatments did not affect the hearing function permanently.

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Don’t forget ototoxicity during the SARS-CoV-2 (Covid-19) pandemic!

Cited by 26 publications

References 12 publications

Changes in Tinnitus Experiences During the COVID-19 Pandemic

Changes in Tinnitus Experiences During the COVID-19 Pandemic

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Mild and moderate COVID-19 disease does not affect hearing function permanently: a cross-sectional study ınvolving young and middle-aged healthcare givers

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