Don't Blame It on the Sunshine, Don't Blame It on the Moonlight, Don't Blame It on Good Times: Blame It on the Sociocultural Factors

Letter to the Editor: mTOR‐Inhibitor‐Based Immunosuppression Following Liver Transplantation for Hereditary Hemorrhagic Telangiectasia

“…Thus, it can be assumed that sociocultural factors appear to be more important than cold weather in eliciting the habit of alcohol drinking and AAF of cirrhosis in different locations such as Taiwan and Ireland. (4)…”

“…(3) PI3K pathway inhibition with rapamycin normalized endothelial cell hyperproliferation and pericyte coverage in postnatal retinas and stimulated vascular malformations regression in a mouse model. (4) Mammalian target of rapamycin (mTOR) inhibitors have been thoroughly tested in patients with LT and are specially recommended in patients with LT for hepatocellular carcinoma. (5) We suggest that the use of an mTOR inhibitor-based immunosuppression regimen may be useful for patients with HHT and LT to avoid vascular growth and reduce recurrence rate.…”

Letter to the Editor: Can Colder Weather and Fewer Sunlight Hours Truly Increase Alcohol Consumption and Alcoholic Cirrhosis?

“…Thus, it can be assumed that sociocultural factors appear to be more important than cold weather in eliciting the habit of alcohol drinking and AAF of cirrhosis in different locations such as Taiwan and Ireland. (4) Gin-Ho Lo, M.D.…”

Association between temperature, sunlight hours and alcohol consumption

“…However, these findings seem counter-intuitive from a northern European perspective, and the research methodology and interpretations were disputed in an accompanying editorial by experienced epidemiologists [2]. Despite a colder climate and significantly less yearly hours of sunlight, mean alcohol consumption in the Nordic countries is lower compared to countries in southern Europe [3].…”