Domperidone, Parkinson disease and sudden cardiac death: Mice and men show the way

Scorza, Fúlvio A.; Scorza, Carla A.; Ferraz, Henrique B.

doi:10.6061/clinics/2016(02)01

Cited by 15 publications

(28 citation statements)

References 47 publications

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“…Although increasing insight into the course and pathomechanisms of PD has been achieved, including risk factors that increase mortality rates, much of the disease remains a mystery 5 , 10 - 12 , 19 , 20 . Importantly, previous studies suggest that PD is not a benign condition and is occasionally associated with sudden unexpected death in PD (SUDPAR) 21 , 22 .…”

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confidence: 99%

“…The causes of SUDPAR are unknown, but cardiovascular risk factors (∼60% of people with PD have cardiovascular abnormalities) may play an important role 22 - 25 . Notably, one practical problem in studying the risk factors, mechanisms and prevention of SUDPAR is that the condition is relatively uncommon.…”

mentioning

confidence: 99%

“…Notably, one practical problem in studying the risk factors, mechanisms and prevention of SUDPAR is that the condition is relatively uncommon. Therefore, the development of translational studies in PD patients who carry a high risk of premature mortality would be of interest to researchers 21 , 22 . Matsumoto et al reviewed clinical data and the causes of death of 16 PD patients who underwent postmortem examinations 23 .…”

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confidence: 99%

See 2 more Smart Citations

Sudden unexpected death in Parkinson's disease (SUDPAR): a review of publications since the decade of the brain

Scorza¹,

Carmo²,

Fiorini³

et al. 2017

Clinics

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Sudden unexpected death in Parkinson's disease (SUDPAR): a review of publications since the decade of the brain

Scorza¹,

Carmo²,

Fiorini³

et al. 2017

Clinics

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“…It has been recognized that PD has a reduced life expectancy due to increased mortality compared to the general population. 3,[11][12][13][14] So far, there is no generally accepted definition for SUDPAR. 7,8 Main causes of death in PD identified by most of the studies are pneumonia and cardiovascular diseases.…”

mentioning

confidence: 99%

“…11 Surprisingly, what is still under debate is the occurrence of "Sudden Unexpected Death in Parkinson's Disease" (SUDPAR). 3,[11][12][13][14] So far, there is no generally accepted definition for SUDPAR. Concerning a didactic definition, SUDPAR was conceptualized as an unexpected death in a patient with PD without any satisfactory explanation of death as determined by autopsy studies.…”

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confidence: 99%

In brief: Sudden unexpected death in Parkinson's disease

et al. 2018

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Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease

Shi,

Du,

et al. 2023

J of Clinical Ultrasound

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AimThis study aimed to evaluate cardiac function, particularly left ventricular systolic function, in patients with Parkinson disease (PD) using velocity vector imaging (VVI), and to determine whether a correlation exists between left ventricular global systolic function and PD severity.MethodsA case–control study design was used to select 56 PD patients and 30 healthy controls from January 2019 to December 2019. The characteristics of age, sex, BMI and course of disease were collected. The Hoehn–Yahr (H‐Y) score was collected to record the grading of PD. The left ventricular systolic function of all patients was evaluated by variable vapor injection (VVI). The left ventricular systolic function was compared between the case group and the control group, and the correlation between cardiac dysfunction and the severity of PD symptoms was assessed using the modified H‐Y scale.ResultsCompared with control group, left ventricular global systolic function18.22 (17.08, 19.12) vs 18.88 (18.12, 20.01) was lower in PD patients as indicated by left ventricular global longitudinal strain (GLS), and the difference was statistically significant (P = 0.039). Additionally, H‐Y scores (r = −0.404) and PD duration(r = −0.323) were significantly correlated with reduced left ventricular ejection fraction (P < 0.01), GLS (P < 0.001), left ventricular global radial strain (GRS; P < 0.001), and left ventricular global circumferential strain (GCS; P < 0.001), along with their associated peak strain rates (GLSr, GRSr, and GCSr; P < 0.001).ConclusionSubclinical left ventricular global systolic dysfunction in patients with PD can be detected using VVI, and reduced left ventricular systolic function correlates with the modified H‐Y score and duration of the disease.

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Domperidone, Parkinson disease and sudden cardiac death: Mice and men show the way

Cited by 15 publications

References 47 publications

Sudden unexpected death in Parkinson's disease (SUDPAR): a review of publications since the decade of the brain

Sudden unexpected death in Parkinson's disease (SUDPAR): a review of publications since the decade of the brain

In brief: Sudden unexpected death in Parkinson's disease

Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease

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