Domperidone-induced dystonia: a rare and troublesome complication

Dhakal, Om Prakash; Dhakal, Mona; Bhandari, Dhurba

doi:10.1136/bcr-2013-200282

Cited by 14 publications

(11 citation statements)

References 13 publications

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“…First, our model outputs that A03F (propulsive) had a high importance ratio for inducing anaphylaxis, but this is not listed in the SIDER database. However, we found that Dhakal et al 32 mentioned anaphylaxis as a very rare side effect of Domperidone. Second, our model said G04C (drugs used in benign prostatic hypertrophy) was important for inducing agranulocytosis, but this is also not listed in the SIDER database.…”

Section: Discussionmentioning

confidence: 66%

Machine Learning Approach for Active Vaccine Safety Monitoring

et al. 2021

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Background Vaccine safety surveillance is important because it is related to vaccine hesitancy, which affects vaccination rate. To increase confidence in vaccination, the active monitoring of vaccine adverse events is important. For effective active surveillance, we developed and verified a machine learning-based active surveillance system using national claim data. Methods We used two databases, one from the Korea Disease Control and Prevention Agency, which contains flu vaccination records for the elderly, and another from the National Health Insurance Service, which contains the claim data of vaccinated people. We developed a case-crossover design based machine learning model to predict the health outcome of interest events (anaphylaxis and agranulocytosis) using a random forest. Feature importance values were evaluated to determine candidate associations with each outcome. We investigated the relationship of the features to each event via a literature review, comparison with the Side Effect Resource, and using the Local Interpretable Model-agnostic Explanation method. Results The trained model predicted each health outcome of interest with a high accuracy (approximately 70%). We found literature supporting our results, and most of the important drug-related features were listed in the Side Effect Resource database as inducing the health outcome of interest. For anaphylaxis, flu vaccination ranked high in our feature importance analysis and had a positive association in Local Interpretable Model-Agnostic Explanation analysis. Although the feature importance of vaccination was lower for agranulocytosis, it also had a positive relationship in the Local Interpretable Model-Agnostic Explanation analysis. Conclusion We developed a machine learning-based active surveillance system for detecting possible factors that can induce adverse events using health claim and vaccination databases. The results of the study demonstrated a potentially useful application of two linked national health record databases. Our model can contribute to the establishment of a system for conducting active surveillance on vaccination.

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Section: Discussionmentioning

confidence: 66%

Machine Learning Approach for Active Vaccine Safety Monitoring

et al. 2021

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“…Acute dystonia is a frequent side effect of antidopaminergic drugs. At paediatric age, DID is most commonly caused by antiemetic drugs (eg, metoclopramide and domperidone),3 4 followed by antipsychotic drugs (eg, haloperidol) used for epilepsy or psychiatric diseases 5. Nevertheless, data on the causes, clinical features and management of DID in children are lacking.…”

Section: Discussionmentioning

confidence: 99%

Involuntary movements in an adolescent: what are the causes?

et al. 2019

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Involuntary movements can be a troublesome condition and represent a real challenge for emergency doctors, particularly for patients of paediatric age. We report a case of a 17-year-old boy with painful involuntary movements mostly affecting his mouth and lower limbs, but also the trunk. After reviewing the patient’s history, it was revealed that the adolescent had had acute alcohol intoxication with severe acute agitation and therefore was given a single dose of 10 mg intravenous haloperidol. The concealment of the recent event posed serious difficulties in reaching the diagnosis. When the diagnosis of haloperidol-induced acute dystonia was made, 3 mg of intravenous biperiden was promptly administered with complete clinical resolution in 15 min.

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“…Extrapyramidal symptoms such as dystonias, Parkinsonism, akathisia, and tardive dyskinesia are side effects of centrally acting D2 antagonists, such as antipsychotics. Rarely, these side effects are observed with domperidone use, especially in infants and young children due to the poorly developed blood-brain barrier [5]. Drug-induced dystonia may be confused with different conditions such as partial seizure, encephalitis, tetany, tetanus, and electrolyte imbalances.…”

Section: Discussionmentioning

confidence: 99%

“…Domperidone-induced acute dystonias are reversible and treated with parenteral administration of anticholinergics such as benztropine or diphenhydramine. Antihistamines having an anticholinergic action such as promethazine are also helpful [5,9].…”

Section: Discussionmentioning

confidence: 99%

Acute Dystonia Secondary to Domperidone in a Pediatric Patient

Shahbaz

Elahi

Affan

et al. 2018

Cureus

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Domperidone is a dopamine-2 receptor (D2) antagonist. It is used as an antiemetic and has an excellent safety profile. We present a case of acute dystonia secondary to domperidone use in an 11-year-old girl. She was admitted with the diagnosis of viral gastroenteritis and received domperidone for persistent vomiting along with other supportive measures. The vomiting subsided with treatment, but she developed acute dystonia. Domperidone discontinued, and her condition improved in the next 24 hours. The patient discharged, and on a follow-up visit, she was asymptotic. A review of the literature suggests a possible association of acute dystonia with domperidone in children.

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Domperidone-induced dystonia: a rare and troublesome complication

Cited by 14 publications

References 13 publications

Machine Learning Approach for Active Vaccine Safety Monitoring

Machine Learning Approach for Active Vaccine Safety Monitoring

Involuntary movements in an adolescent: what are the causes?

Acute Dystonia Secondary to Domperidone in a Pediatric Patient

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