Domperidone and Lactation

Hofmeyr, G Justus; Iddekinge, B. Van

doi:10.1016/s0140-6736(83)91818-4

Cited by 37 publications

(28 citation statements)

References 6 publications

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“…It is transferred to maternal milk in slight quantities due to its high molecular weight and its 90% binding to plasma proteins (30). After administering 10 mg of domperidone 3 times a day for 4 days Hofmeyer et al found a concentration in serum and in milk, of 10 and 2.6 ng/ml respectively (31). In another study the same authors found that the concentrations in serum and in milk to be 8.0 and 0.24 ng/ml, respectively, with an M/P ratio of 0.03, 2 h after the administration of a single dose of 20 mg of domperidone.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…No of side effects has been reported in the infants whose mothers take domperidone (31,32,40,41). Mothers with cardiac diseases should avoid using this drug due to potential arrythmia (43).…”

Section: Side Effects For Mother and For Infantmentioning

confidence: 99%

“…Mothers with cardiac diseases should avoid using this drug due to potential arrythmia (43). Domperidone is less permeable through the blood/brain barrier than metoclopramide as it is less soluble, has a higher molecular weight and binds to plasma proteins more strongly (31,39,41,44). This chemical properties reduce adverse extrapyramidal effects rendering domperidone a good alternative to metoclopramide as a galactagogues.…”

Section: Side Effects For Mother and For Infantmentioning

confidence: 99%

“…Recommended dosage for galactagogic effect: 10 mg po, 3 times a day for 1-2 weeks (31,32,40). However, additional investigations are necessary to determine the minimum effective dose and the needed duration of therapy (43).…”

Section: Side Effects For Mother and For Infantmentioning

confidence: 99%

See 3 more Smart Citations

Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production

Zuppa¹,

Sindico²,

Orchi³

et al. 2010

J Pharm Pharm Sci

165

168

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Poor production of breast milk is the most frequent cause of breast lactation failure. Often, physician prescribe medications or other substances to solve this problem. The use of galactogogues should be limited to those situations in which reduced milk production from treatable causes has been excluded. One of the most frequent indication for the use of galactogogues is the diminution of milk production in mothers using indirect lactation, particularly in the case of preterm birth. The objective of this review is to analyze to the literature relating to the principal drugs used as galactogogues (metoclopramide, domperidone, chlorpromazine, sulpiride, oxytocin, growth hormone, thyrotrophin releasing hormone, medroxyprogesterone). Have been also analyzed galactogogues based on herbs and other natural substances (fenugreek, galega and milk thistle). We have evaluated their mechanism of action, transfer to maternal milk, effectiveness and potential side effects for mother and infant, suggested doses for galactogogic effect, and recommendation for breastfeeding.

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Section: Mechanism Of Actionmentioning

confidence: 99%

Section: Side Effects For Mother and For Infantmentioning

confidence: 99%

Section: Side Effects For Mother and For Infantmentioning

confidence: 99%

Section: Side Effects For Mother and For Infantmentioning

confidence: 99%

See 2 more Smart Citations

Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production

Zuppa¹,

Sindico²,

Orchi³

et al. 2010

J Pharm Pharm Sci

165

168

View full text Add to dashboard Cite

show abstract

“…Adverse effects that have been reported after oral administration of domperidone include headache, dry mouth, diarrhea, itching, muscle cramps, and anxiety [16]. Several studies have shown that domperidone does not readily cross the placental barrier and is present at very low levels in breast milk from mothers treated with oral domperidone [17][18][19][20][21]. As a result, domperidone is considered compatible with breastfeeding by the American Academy of Pediatrics [12].…”

Section: Introductionmentioning

confidence: 99%