Domoic acid induced seizure activity in rats

Dakshinamurti, K.; Sharma, Sushil; Sundaram, M.

doi:10.1016/0304-3940(91)90792-r

Cited by 62 publications

(33 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacokinetics studies have indicated that DA is rapidly cleared from serum and the agents that disrupt kidney function increase the toxicity of DA . DA-induced status epilepticus resulted in long-term deficits in learning, behavior and seizure susceptibility in mature rats, but had no discernible effect in rats <20 days of age (Dakshinamurti et al, 1991). According to this study, the crucial factor associated with increased toxicity in older age groups may be due to decreased renal clearance of DA.…”

Section: Introductionmentioning

confidence: 85%

“…It has been well documented that systemic administration of DA results in neuronal damage in selected areas of the brain, predominantly in the limbic system (Dakshinamurti et al, 1991;Appel et al, 1997). DA is not only a natural toxin but also a rare glutamate analogue, which belongs to the group of excitatory tricarboxylic amino acids (Arias et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Domoic acid-induced neurotoxicity in the hippocampus of adult rats

2004

View full text Add to dashboard Cite

Domoic acid (DA), an agonist of non-N-methyl-D-aspartate (non-NMDA) receptor subtype including kainate receptor, was identified as a potent neurotoxin showing involvement in neuropathological processes like neuronal degeneration and atrophy. In the past decade evidence indicating a role for excitatory amino acids in association with neurological disorders has been accumulating. Although the mechanisms underlying the neuronal damage induced by DA are not yet fully understood, many intracellular processes are thought to contribute towards DA-induced excitotoxic injury, acting in combination leading to cell death. In this review article, we report the leading hypotheses in the understanding of DA-induced neurotoxicity, which focus on the role of DA in neuropathological manifestations, the formation of the retrograde messenger molecule nitric oxide (NO) for the production of free radicals in the development of neuronal damage, the activation of glial cells (microglia and astrocytes) in response to DA-induced neuronal damage and the neuroprotective role of melatonin as a free radical scavenger or antioxidant in DA-induced neurotoxicity. The possible implications of molecular mechanism underlying the neurotoxicity in association with necrosis, apoptosis, nitric oxide synthases (nNos and iNOS) and glutamate receptors (NMDAR1 and GluR2) related genes and their expression in DA-induced neuronal damage in the hippocampus have been discussed.

show abstract

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Domoic acid-induced neurotoxicity in the hippocampus of adult rats

2004

View full text Add to dashboard Cite

show abstract

“…We have reported that domoic acid administration resulted in brain regional GAD inactivation and enhanced of glutamate release. Local cerebral administrations of either GABA or pyridoxine attenuated the domoic acidinduced seizure activity (Dakshinamurti et al, 1991). Serotonin depletion might also play an important role directly or indirectly through modulation of GABA system in seizure susceptibility.…”

Section: Discussionmentioning

confidence: 99%

“…We have reported that microinjections of domoic acid (10-300 pmol) in the hippocampal CA-3 region induced generalized bilateral seizure discharge activity in rats (Dakshinamurti et al, 1991). In the present study we have examined the effects of the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), and the specific 5-HT1A antagonist, spiroxatrine (Nelson and Taylor, 1986) on domoic acid-induced seizure activity in the ipsilateral rat hippocampal CA-3 region.…”

Section: Introductionmentioning

confidence: 99%

Suppression of domoic acid induced seizures by 8-(OH)-DPAT

Sharma

Dakshinamurti

1993

J. Neural Transmission

Self Cite

View full text Add to dashboard Cite

Microinjections of the neuroexcitotoxin, domoic acid (DOM), in the ipsilateral rat hippocampal CA-3 region, induced generalized electrical seizure discharge activity, characterized by spikes and waves, followed by intermittent burst discharges. Computerized EEG analysis exhibited relative dominance of delta and theta and reductions in alpha and beta activities during domoic acid epileptogenesis. Seizure discharge activity was attenuated by the microinjection of the 5-HT1A agonist, 8-hydroxy-2-(di-N-propylamino)tetralin(8-(OH)-DPAT) and augmented by the specific 5-HT1A antagonist, spiroxatrine in the contralateral hippocampal CA-3 region. Neuronal recovery following 8-(OH)-DPAT was associated with significant reductions in the relative dominance of delta and theta and increases in the alpha and beta activities. The results suggest that activation of serotonergic 5-HT1A receptor in the hippocampus has a neuroprotective action.

show abstract

“…Critically, variations in excitatory tone are associated with deficits in social functioning [61] and in heightened seizure susceptibility [54,[62][63][64]. Exposure to toxic levels of DA and ASD also share in common abnormalities in limbic structures [64,65], particularly the hippocampus [66][67][68][69] and the amygdala [64,70,71], along with possible similarities in connectivity [72,73].…”

Section: Toxicity Of Domoic Acidmentioning

confidence: 99%

What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine

Lahvis

2017

EPMA Journal

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species of Pseudo-nitzschia. Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. The mammalian fetus is highly sensitive to the deleterious effects of DA exposure. Both ASD and exposures to toxic levels of DA feature repetitive behaviors, challenges with social interaction, and seizures. They can also share a commonality in brain anatomy and function, particularly the balance between excitatory and inhibitory mechanisms. The current article is relevant to predictive, preventive, and personalized medicine for three reasons. First, shellfish consumption may be a risk factor for ASD and the regulatory limit for DA should be adjusted to prevent this possibility. Human contributions to increased algal production of DA in coastal waters should be identified and reduced. Second, evaluations of sentinel species wild and free-roaming in the environment, though typically outside the purview of biomedical research, should be much more fully employed to gain insights to risk factors for human disease. To better identify and prevent disease, biomedical researchers shouldstudy wildpopulations.Third, studies of DA exposure highlight the possibility that glutamate additives to processed foods may also have deleterious impacts on human brain development and behavior.Keywords Domoic acid . Autism spectrum disorder . Glutamate . Behavior . Anatomy . Brain . Development . Predictive diagnosis . Targeted prevention . Population screening Autism and its prevalenceAutism spectrum disorder (ASD) is often diagnosed early in childhood and features deficits in social interaction and communication and includes repetitive behaviors and circumscribed interests [1,2]. The prevalence of autism is more common among boys than girls [3] and has increased substantially over the past 20 years [3,4]. ASD is the most highly heritable developmental disability yet researchers have identified only a few genetic susceptibility factors [5][6][7][8][9][10] that can account for a small fraction of the diagnosed population [10].

show abstract

Domoic acid induced seizure activity in rats

Cited by 62 publications

References 13 publications

Domoic acid-induced neurotoxicity in the hippocampus of adult rats

Domoic acid-induced neurotoxicity in the hippocampus of adult rats

Suppression of domoic acid induced seizures by 8-(OH)-DPAT

What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine

Contact Info

Product

Resources

About