Domino Condensation/S‐Arylation/Heterocyclization Reactions: Copper‐Catalyzed Three‐Component Synthesis of 2‐N‐Substituted Benzothiazoles

Domino Reactions Initiated by Copper‐Catalyzed Aryl‐I Bond Thiolation For the Switchable Synthesis of 2,3‐Dihydrobenzothiazinones and Benzoisothiazolones

“…[3] In addition, the CÀS coupling-based domino reactions between ohaloanilines and carbon disulfide giving benzothiaozles are also achieved. [4] Bao and co-workers devel-oped the synthetic method toward 2-iminobenzo-1,3oxathioles via the assemblies of o-iodophenols and isothiocyanates. [5] Zeng et al have identified the copper-catalyzed one-pot synthesis of phenothiazines via the reactions of aryl o-dihalides and o-aminothiphenols via tandem CÀN and CÀS coupling.…”

“…[5] Zeng et al have identified the copper-catalyzed one-pot synthesis of phenothiazines via the reactions of aryl o-dihalides and o-aminothiphenols via tandem CÀN and CÀS coupling. [6] Wen and Li et al have developed the domino reactions of obromo-arylisothiocyanates and aroylhydrazides as synthetic route to benzo [4,5]thiazolo [2,3-c] [1,2,4]triazoles. [7] Furthermore, the synthesis of 2H-benzo[b] [1,4] thiazin-3(4H)-ones, [8] benzothiophenes, [9] 2-aminobenzothiazoles, [10] benzisothiazol-3(2H)-ones, [11] 2-(arylthio)arylcyanamides, [12] as well as thiazino [2,3,4-hi]indoles [13] have also been reported.…”

Development of Divergent Synthetic Methods of Pyrimidobenzothiazine and Related Tricyclic Heterocycles

“…With these findings [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53], the author investigated the transition-metal (Pd, Cu, Fe, etc.) catalyzed coupling of haloarenes 6aa and heterocumulenes.…”

Catalyst‐Free Regio‐ and Stereospecific Synthesis of β‐Sulfonamido Dithiocarbamates: Efficient Ring‐Opening Reactions of N‐Tosyl Aziridines by Dialkyldithiocarbamates

“…[8c,d] Additionally, dithiocarbamates serve as the precursors for substituted thiazole derivatives, which are potential anti-HIV agents, antibacterial agents, and phosphodiesterase 10 inhibitors. [9,10] Interestingly, in most of the reactions that achieve such compounds, thiocarbamates are treated with halides in the presence of a metal catalyst to form C À S bonds. [10] Hence, the development of new synthetic routes to accomplish functionalized dithiocarbamates has been an attractive field of research for organic chemists for the past few decades.…”

“…[9,10] Interestingly, in most of the reactions that achieve such compounds, thiocarbamates are treated with halides in the presence of a metal catalyst to form C À S bonds. [10] Hence, the development of new synthetic routes to accomplish functionalized dithiocarbamates has been an attractive field of research for organic chemists for the past few decades. [11] Interestingly, aziridines are versatile building blocks for the synthesis of biologically important compounds.…”