“Domino” cascade reactor based on DNA hydrogel for synergistic treatment of malignant tumor

Liu, Xiaofan; Ma, Minghui; Tian, Shu; Wang, Weicai; Li, Xuemei

doi:10.1016/j.ejmech.2023.115441

Cited by 6 publications

(1 citation statement)

References 52 publications

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“…125 It is well-known that each cancer monotherapy has some drawbacks, so more and more research is turning to synergistic therapies that combine multiple treatment modalities. Therefore, Li et al 126 constructed a DNA hybrid hydrogel-based "domino" cascade reactor for cancer-targeted starvation therapy and amplified PDT. This method enhances photodynamic therapy (PDT) by assembling heme and glucose oxidase (GOx) into DNA hydrogels loaded with hypoxiainducible factor-1 α (HIF-1 α) and photosensitizer chloroprotein e6 (Ce6).…”

Section: Immunotherapy Drug Deliverymentioning

confidence: 99%

Intelligent DNA-Based Hydrogels for Bioanalysis and Therapeutics

Zhu,

Shen,

Chen

et al. 2023

ACS Appl. Polym. Mater.

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DNA is a type of biomacromolecule that can be modified and designed through enzymatic or chemical techniques, and it serves as both a biological reactive entity and a polymer. In recent years, with the rapid development of chemistry, material science, and nanotechnology, researchers began to look at the DNA molecule from another perspective. The exceptional ability of DNA-based materials for selective recognition and structural design has attracted much attention. With the development of nanotechnology, there is an urgent need for smart hydrogel materials with excellent biocompatibility. Among many nanomaterials, DNA is considered to be an excellent smart material, which can spontaneously self-assemble into a precise and ordered structure under optimal conditions. Chemical bonding between DNA molecules or physical entanglement between DNA strands can be prepared from DNA-based smart hydrogels. Compared with traditional hydrogels, DNA-based hydrogels have the characteristics of functional DNA molecular programming and high-precision assembly, multifunctionality, and excellent biocompatibility and retain the excellent mechanical properties and physical properties of hydrogels. It has attracted increasing research interest in various fields, especially in biosensing and biomedical applications. In this review, we highlight the advances in DNA-based hydrogels for bioanalysis and therapeutics. We first summarize the construction methods and basic properties of DNA-based pure and hybrid hydrogels and discuss their research progress and biological applications. Subsequently, the practical applications of various types of DNA-based hydrogels in the fields of bioanalysis and drug delivery are described through some selected examples. Finally, the remaining challenges and prospects of DNA-based hydrogels are discussed in depth.

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Section: Immunotherapy Drug Deliverymentioning

confidence: 99%

Intelligent DNA-Based Hydrogels for Bioanalysis and Therapeutics

Zhu,

Shen,

Chen

et al. 2023

ACS Appl. Polym. Mater.

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Targeting HIF‐1α with Specific DNA Yokes for Effective Anticancer Therapy

Zhang,

Wu,

Liu

et al. 2024

Adv Healthcare Materials

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Hypoxia, a ubiquitous hallmark in cancer, underscores the significance of targeting HIF‐1α, the principal transcriptional factor of hypoxic responses, for effective cancer therapy. Herein, we introduce DNA yokes, a novel class of DNA nanomaterials harboring specific HIF‐1α binding sequences (hypoxia response elements, HREs), as nano‐pharmaceuticals for cancer treatment. Comprising a basal tetrahedral DNA nanostructure (TDN) and four HRE‐bearing overhanging chains, DNA yokes exhibit exceptional stability and prolonged intracellular retention. Our investigation reveals their capacity to bind HIF‐1α, thereby disrupting its interaction with the downstream genomic DNAs and impeding transcriptional activity. Moreover, DNA yokes facilitate HIF‐1α degradation via the ubiquitination pathway, thereby sequestering it from downstream targets and ultimately promoting its degradation. Additionally, DNA yokes attenuate cancer cell proliferation, migration, and invasion under hypoxic conditions, while also displaying preferential accumulation within tumors, thereby inhibiting tumor growth and metastasis in vivo. This study pioneers a novel approach to cancer therapy through the development of DNA‐based drugs characterized by high stability and low toxicity to normal cells, positioning DNA yokes as promising candidates for cancer treatment.This article is protected by copyright. All rights reserved

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Rational Design of DNA Hydrogels Based on Molecular Dynamics of Polymers

Li,

Chen,

Zhou

et al. 2023

Advanced Materials

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In recent years, DNA has emerged as a fascinating building material to engineer hydrogels due to its excellent programmability, which has gained considerable attention in biomedical applications. Understanding the structure‐property relationship and underlying molecular determinants of DNA hydrogel is essential to precisely tailor its macroscopic properties at molecular level. In this review, we highlight the rational design principles of DNA molecular networks based on molecular dynamics of polymers on the temporal scale, which can be engineered via the backbone rigidity and crosslinking kinetics. By elucidating the underlying molecular mechanisms and theories, we aim to provide a comprehensive overview of how the tunable DNA backbone rigidity and the crosslinking kinetics lead to desirable macroscopic properties of DNA hydrogels, including mechanical properties, diffusive permeability, swelling behaviors, and dynamic features. Furthermore, we also discuss how the tunable macroscopic properties make DNA hydrogels promising candidates for biomedical applications, such as cell culture, tissue engineering, bio‐sensing, and drug delivery.This article is protected by copyright. All rights reserved

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“Domino” cascade reactor based on DNA hydrogel for synergistic treatment of malignant tumor

Cited by 6 publications

References 52 publications

Intelligent DNA-Based Hydrogels for Bioanalysis and Therapeutics

Intelligent DNA-Based Hydrogels for Bioanalysis and Therapeutics

Targeting HIF‐1α with Specific DNA Yokes for Effective Anticancer Therapy

Rational Design of DNA Hydrogels Based on Molecular Dynamics of Polymers

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