Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis.

Grom, Alexei A.; Thompson, Susan D.; Luyrink, Lorie; Passo, Murray H.; Choi, Edmund; Glass, David N.

doi:10.1073/pnas.90.23.11104

Cited by 60 publications

(19 citation statements)

References 27 publications

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“…28,29 The identification of expanded oligoclonal TCRs within and between individual JIA patients has also been previously observed. 30 The common TCR fragments identified in this study, suggest local (synovial) stimulation by a limited number of antigens.…”

Section: Discussionmentioning

confidence: 68%

Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis

Gibson¹,

Blelock²,

Brockbank³

et al. 2006

J. Proteome Res.

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The synovial fluid proteome in juvenile idiopathic arthritis was investigated to isolate joint-specific biomarkers that are expressed in patients displaying recurrent joint inflammation. To identify the synovial specific proteome, matched synovial fluid and plasma samples were subjected to protein separation by 2-dimension electrophoresis (2DE). Forty-three protein spots, overexpressed in the joint, were identified. Synovial fluids from children with single-event knee joint inflammation were then compared with a group with recurrent knee disease. Nine synovial specific proteins were significantly differentially expressed in the recurrent group. Proteolytic fragments of collagen X, fibrin β-chain, and T-cell receptor α-region have been identified among this protein cluster. Putative biomarkers, overexpressed in the joint and differentially expressed in children with recurrent joint inflammation, have been identified. These proteins may play a significant role determining the pathological state within the chronically inflamed joint and influence disease progression in JIA. This is the first study of the synovial proteome in children. Keywords: juvenile idiopathic arthritis • biomarker • inflammation • synovial fluid • plasma

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Section: Discussionmentioning

confidence: 68%

Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis

Gibson¹,

Blelock²,

Brockbank³

et al. 2006

J. Proteome Res.

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“…The very similar frequencies of CCR4 ϩ and CCR5 ϩ T cells found in different joints tested simultaneously are in agreement with this view. Identical expanded T cell clones have also been reported in simultaneous joints (39). The differences between the fraction of CD45RO ϩ memory T cells that express CCR4 ϩ or CCR5 ϩ in the synovial fluid is of interest.…”

Section: Discussionmentioning

confidence: 99%

Chemokine Receptor CCR4 on CD4+ T Cells in Juvenile Rheumatoid Arthritis Synovial Fluid Defines a Subset of Cells with Increased IL-4:IFN-γ mRNA Ratios

Thompson

Luyrink

Graham

et al. 2001

The Journal of Immunology

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To understand the mechanisms that promote recruitment and survival of T cells within the pediatric inflamed joint, we have studied the expression of CCR4 and CCR5 on synovial fluid T cells and matched peripheral blood samples from juvenile rheumatoid arthritis (JRA) patients using three-color flow cytometric analysis. Thymus- and activation-regulated chemokine and macrophage-derived chemokine, ligands for CCR4, were measured by ELISA in JRA synovial fluid, JRA plasma, adult rheumatoid arthritis synovial fluid, and normal plasma. IL-4 and IFN-γ mRNA production was assessed in CD4+/CCR4+ and CD4+/CCR4− cell subsets. We found accumulations of both CCR4+ and CCR5+ T cells in JRA synovial fluids and a correlation for increased numbers of CCR4+ T cells in samples collected early in the disease process. Thymus- and activation-regulated chemokine was detected in JRA synovial fluid and plasma samples, but not in adult rheumatoid arthritis synovial fluid or control plasma. Macrophage-derived chemokine was present in all samples. CD4+/CCR4+ synovial lymphocytes produced more IL-4 and less IFN-γ than CD4+/CCR4− cells. These findings suggest that CCR4+ T cells in the JRA joint may function early in disease in an anti-inflammatory capacity through the production of type 2 cytokines and may play a role in determining disease phenotype.

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“…It has been shown, however, that many patients with rheumatoid arthritis have an elevated percentage of T cells expressing Vβ14 in their synovial fluid, whereas such cells are absent from the peripheral blood [310,311]. T cells isolated from the synovia of patients with rheumatoid arthritis show high proportion of those cells bear Vβ3, Vβ14, and Vβ17 [312].…”

Section: Rheumatoid Arthritismentioning

confidence: 96%

Bacterial superantigens and superantigen-like toxins

Langley

Fraser

Proft

2015

The Comprehensive Sourcebook of Bacterial Protein Toxins

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Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis.

Cited by 60 publications

References 27 publications

Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis

Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis

Chemokine Receptor CCR4 on CD4+ T Cells in Juvenile Rheumatoid Arthritis Synovial Fluid Defines a Subset of Cells with Increased IL-4:IFN-γ mRNA Ratios

Bacterial superantigens and superantigen-like toxins

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