Dominant–submissive behavior as models of mania and depression

Malatyńska, Ewa; Knapp, Richard J.

doi:10.1016/j.neubiorev.2005.03.014

Cited by 119 publications

(109 citation statements)

References 129 publications

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“…We also applied the dominant-submissive social behavior paradigm, in which the relative behavioral tendency toward submissiveness or dominance reflects the behavioral status on the axis between depression and mania. 29,62 FSL rats were recently shown in this model to have a submissive phenotype that was abolished after electrical stimulation of the ventral tegmental area. 30 Our results further show the establishment of dominant behavior in MSC-injected rats compared with submissive behavior observed in their vehicle-injected counterparts (Figure 2b).…”

Section: Discussionmentioning

confidence: 99%

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Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

et al. 2009

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Adult bone marrow-derived mesenchymal stem cells (MSCs) are regarded as potential candidates for treatment of neurodegenerative disorders, because of their ability to promote neurogenesis. MSCs promote neurogenesis by differentiating into neural lineages as well as by expressing neurotrophic factors that enhance the survival and differentiation of neural progenitor cells. Depression has been associated with impaired neurogenesis in the hippocampus and dentate gyrus. Therefore, the aim of this study was to analyze the therapeutic potential of MSCs in the Flinders sensitive line (FSL), a rat animal model for depression. Rats received an intracerebroventricular injection of culture-expanded and 1,1 0 -dioctadecyl-3,3,3 0 ,3 0 -tetramethylindocarbocyanine perchlorate (DiI)-labeled bone marrow-derived MSCs (10 5 cells). MSC-transplanted FSL rats showed significant improvement in their behavioral performance, as measured by the forced swim test and the dominant-submissive relationship (DSR) paradigm. After transplantation, MSCs migrated mainly to the ipsilateral dentate gyrus, CA1 and CA3 regions of the hippocampus, and to a lesser extent to the thalamus, hypothalamus, cortex and contralateral hippocampus. Neurogenesis was increased in the ipsilateral dentate gyrus and hippocampus of engrafted rats (granular cell layer) and was correlated with MSC engraftment and behavioral performance. We therefore postulate that MSCs may serve as a novel modality for treating depressive disorders.

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Section: Discussionmentioning

confidence: 99%

“…29,30 FSL rats were randomly paired. In each pair, the animals were placed in the opposite chambers of the DSR apparatus and were allowed to compete for the milk for a 5-min period after 30 s of acclimation.…”

Section: Dominant-submissive Relationship (Dsr) Paradigmmentioning

confidence: 99%

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

et al. 2009

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“…For a full review of models, see the special issue of Neuroscience and Biobehavioral Reviews (edited by A. Markou) devoted to the topic [52]. We have chosen to use another well standardized model, based on social submission in adult male rats [50,69], to identify the genetic consequences of social loss. The chronic stress that occurs in the presence of persistent loss in aggressive social encounters [2,57 especially in the absence of social support [69,18], is a major factor that sets in motion incompletely understood neurobiological events that leads to affective deficits and depressive disorders [49,57,58,66,81].…”

Section: Introductionmentioning

confidence: 99%

Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray

Kroes¹,

Burgdorf²,

Otto³

et al. 2007

Behavioural Brain Research

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Gene expression profiles in the periaqueductal gray (PAG) of adult Long-Evans rats as a function of a stressful social defeat in inter-male fighting encounters were examined. This social subordination model mimics prototypical behavioral changes that parallel aspects of clinical depression, has been postulated to simulate early changes in the onset of depression in the losers, and has been successfully utilized for the evaluation of antidepressant activity. 22-kHz ultrasonic vocalizations (USVs) have been shown to reflect negative emotional states akin to anxiety and depression. Social defeat is the most robust and reliable method of eliciting these calls. The PAG has been shown to be a key brain region for the generation of 22-kHz ultrasonic vocalizations, and 22-kHz USVs have been shown to be controlled by the mesolimbic cholinergic system. In this present study we examined gene expression changes in the PAG of social subordinate rats compared to dominant rats (that do not exhibit 22-kHz USVs). We found that social defeat significantly altered the genes associated with cholinergic synaptic transmission in the PAG. The most robust of these were the increased expression of the β2 subunit of the nicotinic acetylcholine receptor (CHRNB2) and the T-subunit of acetylcholinesterase (ACHE) in the subordinate animals. These changes were corroborated by qRT-PCR and found to be exclusive to the PAG compared to seven other brain regions examined. These data suggest that cholinergic transmission in the PAG is involved in the generation of 22-kHz USVs and provide potential therapeutic targets for the treatment of affective disorders.

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“…O primeiro baseia-se na manifestação natural de comportamentos de dominância e submissão em roedores para identificação de similaridades sintomatológicas e valor preditivo em relação aos transtornos maníaco e depressivo (Malatynska & Knapp, 2005;Malatynska, Pinhasov, Crooke, Smith-Swintosky, & Brenneman, 2007). Em geral, dois animais co-específicos são submetidos a condições de competição (ex.…”

Section: Modelos Animais Do Transtorno Bipolar -Episódio Maníacounclassified

“…Em geral, dois animais co-específicos são submetidos a condições de competição (ex. alimento) onde se definem relações de dominância e submissão -relações estas sensíveis ao tratamento com drogas anti-maníacas (que reduzem comportamentos de dominância) e antidepressivas (que reduzem comportamentos de submissão) (Malatynska & Knapp, 2005;Malatynska et al, 2007). O segundo modelo baseia-se na administração intracerebroventricular de oubaína (derivado esteroide com propriedade de inibir a ATPase sódio-potássio).…”

Section: Modelos Animais Do Transtorno Bipolar -Episódio Maníacounclassified

Efeitos comportamentais da lesão eletrolítica da região do núcleo mediano da rafe como modelo experimental de mania no rato e no camundongo

Pezzato¹

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Dominant–submissive behavior as models of mania and depression

Cited by 119 publications

References 129 publications

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray

Efeitos comportamentais da lesão eletrolítica da região do núcleo mediano da rafe como modelo experimental de mania no rato e no camundongo

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