“…By 1981, 23 cases of PPNAD (4 from the Mayo Clinic and 19 from the world literature) were available for study; 6 of them involved siblings from two families, one from Cuba and another from Switzerland (17). By 1984, 40 cases were identified, with various combinations of myxomas affecting multiple organs (heart, skin, and breast), spotty skin pigmentation (lentigines and blue nevi), and tumors of three endocrine organs (adrenal, pituitary, and testis) (18). The group had five sets of siblings, adding to the suspicion that the disorder was familial.…”