Dominant inheritance of cerebral gigantism

Sotos Syndrome: A Case Report

“…At least five families have been reported in which both parents and offspring were affected, suggesting an autosomal dominant inheritance. 9,10 The presence of two cousins with a similar problem suggests the possibility of a genetic inheritance of Sotos syndrome in this family.…”

A Case of Sotos Syndrome (Cerebral Gigantism) and Psychosis

“…A sporadic dominant mutation may be involved, though autosomal recessive [16]and autosomal dominant modes of inheritance have been proposed as well [17, 18, 19]. …”

“…The emotional, cognitive, and behavioral characteristics of children with Sotos syndrome have been discussed by several authors [3, 17, 20, 21]. Kjellman [20]reported a case in which a toddler with the syndrome could walk but not speak; and she was noted to be very aggressive, ‘willful’, and avoidant.…”

Urological anomaly in an infant with Sotos’ syndrome: report of a case

“…[2][3][4][5][6][7][8] . De origem ainda desconhecida, diferentes estudos sugerem a origem genética, com transmissão autossômica dominante ou até recessiva [9][10][11][12] .…”