Dominance of Furosemide for Loop Diuretic Therapy in Heart Failure

Diuretic Treatment in Heart Failure

“…2C), one might expect that torsemide should be more effective during typical dosing regimens, but data to support this suggestion are limited. 18 A systematic analysis of torsemide versus furosemide comparative effectiveness suggested that torsemide reduced heart failure readmissions, 19 but available data are limited and the question is well-suited for definitive clinical trials. 20 …”

Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice

“…Here, the experiments in primary cardiac fibroblasts and 37.2%, p < 0.00017) and that fewer patients receiving torsemide died (2.2% vs. 4.5%, p < 0.05) [5]. Additionally, a recent meta-analysis suggests improved functional status and mortality with torsemide compared with furosemide [46].…”

Volume Overload in Heart Failure

“…As a result, 87% of inpatients with ADHF are treated with furosemide, 3% with bumetanide, 0.4% with torsemide, and 10% with a combination of synergistic diuretics. 5 Comparatively, loop diuretics are structurally similar, except for ethacrynic acid, which lacks a sulfa moiety. However, it is associated with a greater risk of ototoxicity, relegating its use to patients with allergies to sulfa-containing medications.…”