Domesticated Cats with Active Mycobacteria Infections have Low Serum Vitamin D (25(OH)D) Concentrations

Lalor, Stephanie; Mellanby, Richard J.; Friend, Ed; Bowlt, Kelly; Berry, Jacqueline; Gunn-Moore, Danièlle

doi:10.1111/j.1865-1682.2011.01265.x

Cited by 36 publications

(35 citation statements)

References 11 publications

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“…Less is known about the relationship between vitamin D status and disease outcomes in cats although studies have documented low serum 25(OH)D levels in diseases including inflammatory bowel disease, gastrointestinal lymphoma and mycobacterial infection (Lalor et al . , ). It has been demonstrated that low serum concentrations 25(OH)D are associated with an increased risk of 30 day mortality in sick cats (Titmarsh et al .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status in cats with feline immunodeficiency virus

Titmarsh

Lalor

Tasker

et al. 2015

Veterinary Medicine & Sci

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Feline immunodeficiency virus (FIV) is a lentivirus that can lead to a syndrome of acquired immune dysfunction. Infected cats often remain asymptomatic for several years before immune dysfunction leads to an increased risk for the development of systemic diseases, neoplasia and opportunistic infections. FIV is structurally related to human immunodeficiency virus (HIV) and the pathogenesis of FIV‐related disease is similar to that seen in HIV‐infected patients. Observational studies have documented an association between low plasma vitamin D and HIV infection. Vitamin D status has been shown to be associated with HIV‐related disease progression, morbidity and mortality. The objective of this study was to examine the hypothesis that vitamin D status, as assessed by serum 25‐hydroxyvitamin D [25(OH)D] concentrations, are lower in cats with FIV infection compared to healthy control cats. Serum 25(OH)D concentrations were measured in 20 healthy cats, 39 hospitalized ill cats and 59 cats infected with FIV. Cats which were FIV infected had significantly lower 25(OH)D concentrations compared to healthy control cats. Serum 25(OH)D concentrations were not significantly different between FIV‐infected cats and hospitalized ill cats. Further investigations are warranted to determine whether vitamin D status influences the prognosis of cats infected with FIV.

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Section: Discussionmentioning

confidence: 99%

Vitamin D status in cats with feline immunodeficiency virus

Titmarsh

Lalor

Tasker

et al. 2015

Veterinary Medicine & Sci

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“…This confirms that far from being rare, clinically significant mycobacterial infections occur commonly in cats in GB. 2011a,b;Lalor et al, 2012;Rhodes et al, 2011;Rüfenacht et al, 2011;reviewed in Greene and Gunn-Moore, 2012), their current prevalence remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, many aspects of mycobacteriosis in this species remain unknown. While recent studies from Great Britain (GB) have advanced our overall understanding of these infections (reviewed in Gunn‐Moore, 2010; Bennett et al., 2011; Gunn‐Moore et al., 2011a,b; Lalor et al., 2012; Rhodes et al., 2011; Rüfenacht et al., 2011; reviewed in Greene and Gunn‐Moore, 2012), their current prevalence remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Mycobacterial Infections in Cats in Great Britain: Estimate from Feline Tissue Samples Submitted to Diagnostic Laboratories

Gunn-Moore

Gaunt

Shaw

2012

Transboundary and Emerging Diseases

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The aim of this study was to estimate the incidence of mycobacterial infections in cats in Great Britain (GB). This was performed using the proxy measure of feline tissue samples submitted to diagnostic laboratories in GB that were found to have histopathological changes typical of mycobacterial infection ('MYC'). Sixteen primary diagnostic laboratories were asked for information on the number of feline samples submitted in 2009, the number with MYC, the number undergoing Ziehl-Neelsen (ZN) staining and, for comparison, the number diagnosed with lymphoma. Eight laboratories provided full data for the whole year: 11,782 samples; lymphoma 3.2% (mean, 95% CI: 2.89, 3.5), MYC 1.16% (0.98; 1.37) and ZN-positive 0.31% (0.22; 0.43). Data on 1569 samples from seven laboratories that provided partial data on samples for the whole year revealed similar results, although all changes were more frequent: lymphoma 5.42% (4.35; 6.66), MYC 2.36% (1.66; 3.23) and ZN-positive 0.77% (0.40; 1.33). One laboratory only provided data for part of the year (4.5 months), reporting all three types of histopathology less frequently: 18,232 samples; lymphoma 0.2% (0.18; 0.32), MYC 0.07% (0.04; 0.12) and ZN-positive 0.05% (0.02; 0.09). The reasons for low reporting rates in this high-throughput laboratory are unclear. In total, 187 samples were reported as having MYC. Five Reference laboratories were also contacted, reporting 174 feline tissue submissions in 2009, with mycobacteria being cultured from 90. The study shows that MYC are frequently reported in tissue samples from cats in GB, being reported in ~1% of samples, with confirmation as ZN-positive in ~0.3%. Lymphoma is recognized as a common disease in cats, being seen in ~3% of samples in this study. When compared against MYC, lymphoma was reported only twice as frequently. This confirms that far from being rare, clinically significant mycobacterial infections occur commonly in cats in GB.

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“…A recent study found that cats with mycobacterial infections had lower serum 25(OH)D concentrations than healthy cats (Lalor et al . ).…”

Section: Vitamin D – An Overviewmentioning

confidence: 97%