Domestic poultry are not susceptible to avian-origin H3N2 subtype canine influenza A virus

The Evolution and Epidemiology of H3N2 Canine Influenza Virus After 20 Years in Dogs

“…While swine appear to be intermediate host that allows influenza viruses to jump onward into humans to cause sustained epidemics on at least a few occasions, other mammalian-adapted influenza viruses (in horses, seals, cows, mink) have so-far not proved to be clear threats to humans [3]. The changes in the H3N2 CIV have included previously identified mammalian-adaptive sites [23], some experimentally confirmed as having biological effects [49], and the H3N2 CIV appears to lost the host range for at least some avian hosts [69]. Other concerning adaptive changes that underlie known human adaptation and pandemic risk (including NP changes to evade MxA/BTN3A3 restriction factors, and HA RBD changes to the 226/228 dyad) are absent, as the H3N2 CIV remains 'avian-like' [70][71][72].…”