Domestic allergens in public places III: house dust mite, cat, dog and cockroach allergens in British hospitals

Čustović, Adnan; Fletcher, A. M.; Pickering, Christopher; Francis, Helen; Green, Rosalind; Smith, Anderson D.; Chapman, Martin D.; Woodcock, Ashley

doi:10.1046/j.1365-2222.1998.00183.x

Cited by 127 publications

(87 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allergic sensitisation to dog or cat allergens is believed to be an important risk factor for asthma and asthma symptoms, [1][2][3][4][5][6][7][8][9][10][11][12] and many studies reported positive correlations between the ownerships of pets and the excess in the occurrence of asthma symptoms, asthma diagnosis or asthma medication treatment. It was also shown that asthmatics are more likely than nonasthmatics sensitised to pet allergens and exposures to Can f 1 and Fel d 1 as low as 2 mg/g of house dust and 1 mg/g of dust, respectively, have been assumed as clinically relevant risk thresholds [13][14][15]. Although an exposure to indoor allergens may be significant for the occurrence of allergic symptoms at any time, but the conditions under which exposure takes place early in life seem to be particularly important for sensitisation.…”

Section: Introductionmentioning

confidence: 99%

Validity of the interview on pets kept at home for predicting the actual domestic expsoure to their specific allergens. Krakow inner city area study

et al. 2008

View full text Add to dashboard Cite

AbstractThe aim of the study was to describe the exposure to dog (Can f 1) and cat (Fel d 1) allergens within homes of very young children living with and without pets, and to assess the validity of the interview on pets for predicting the actual exposure to pet allergens in house dust. House dust samples were collected in 275 dwellings from the mattresses, children’s bedroom and kitchen floors. In the laboratory, dust samples were analyzed for Can f 1 and Fel d 1 using monoclonal antibody enzyme-linked immunosorbent assays (ELISA). The majority of households (79.3%) had neither a dog nor a cat living in the home over the past 6 months preceding the survey. Dog allergen above 2 μg/g dust were found in 22.5% of homes and 14.2% of homes contained dog allergen above 10 μg/g of house dust. In the total study sample, cat allergen above 1 μg/g of dust were found in 12.7% of homes, and 3.3% of homes contained Fel d 1 levels greater than 8 μg/g of dust. The majority of children (75.0%) with reported ownership of dogs were exposed to Can f 1 levels above 2 μg/g of house dust, and 73.1% of children with cats at home were exposed to Fel d 1 concentrations above 1 μg/g house dust. The results of the study showed that post-test probability of the true exposure to Can f 1 above 2 μg/g dust in houses with positive interview on indoor dogs was 75.0% (95%CI: 61.7–84.8%). On the other hand, the prediction of exposure estimated from the interview data on indoor dogs produced 12.6% of false negatives (95% CI: 9.9–15.8%). Similarly, the post-test probability of the true exposure to Fel d 1 above 1 μg/g dust in houses with positive interview on indoor cats was 73.1% (95%CI: 55.1–85.7%). On the other hand, the interview data produced 6.4% false negatives (95% CI: 4.6–9.0%). In conclusion, the study demonstrated that homes in Poland with pet ownership are important reservoir of Can f 1 and Fel d 1 allergens with levels that might induce allergic symptoms. Even in homes of children without a dog or cat indoors, there was a higher prevalence of pet allergens at the levels above allergic sensitisation thresholds. This may have an important implication for epidemiologic studies on pet related allergy and prevention practice.

show abstract

Section: Introductionmentioning

confidence: 99%

Validity of the interview on pets kept at home for predicting the actual domestic expsoure to their specific allergens. Krakow inner city area study

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Airborne allergens are present in most homes and in many indoor public areas like schools, day care centres and official buildings [1][2][3][4]. It has also been demonstrated that it is difficult to reduce allergen exposure in these environments [5][6][7].…”

mentioning

confidence: 99%

Reduced late asthmatic response by repeated low-dose allergen exposure

et al. 2001

View full text Add to dashboard Cite

Reduced late asthmatic response by repeated low-dose allergen exposure. M. Palmqvist, Z-H. Cui, M. Sjöstrand, A. Lindén, J.Lötvall. #ERS Journals Ltd 2001. ABSTRACT: Allergic asthmatic individuals are often exposed to low-doses of allergen in their everyday life. Extended exposure to allergen has lead to down-regulation of the allergic process in cell systems and in animal models. The aim of this study was to evaluate whether any such inhibitory mechanism of allergic responses can be seen in man in vivo.Patients with mild asthma were repeatedly and double-blindly exposed to 25% of the individual dose of allergen that caused an early (EAR) and late asthmatic reaction (LAR). One day after the low-dose allergen or placebo exposure periods, the same individual was given a high-dose allergen challenge. Sputum and blood were collected for the evaluation of eosinophils.Exposure to repeated low doses of allergen induced increased bronchial methacholine responsiveness 6 h after the final allergen exposure (p~0.018), and an increase in the number of eosinophils in sputum. By contrast, the late asthmatic response after challenge with a high dose of allergen was significantly attenuated by y30% at 24 h after the final low-dose allergen exposure (p~0.03).In summary, repeated low doses of allergen given directly to the airways, attenuate the high-dose allergen-induced late response, despite enhanced bronchial hyperresponsiveness to methacholine and elevated sputum eosinophils prior to allergen challenge.

show abstract

“…Cat and dog allergens are transported on the clothing of people (such as employees and visitors) who have household pets to pet-free areas such as workplaces [Perfetti et al 2004]. Multiple studies have shown dog and cat allergens on carpet and often much higher levels on upholstered chairs in public places and indoor workplaces [Custovic et al 1996[Custovic et al , 1998Perfetti et al 2004]. These passively transferred allergens can become airborne and cause respiratory symptoms in individuals allergic to cats or dogs.…”

Section: Cat and Dog Allergensmentioning

confidence: 99%

Health hazard evaluation report: evaluation of indoor environmental quality at an accounting office, Florida.

2013

View full text Add to dashboard Cite

Domestic allergens in public places III: house dust mite, cat, dog and cockroach allergens in British hospitals

Cited by 127 publications

References 21 publications

Validity of the interview on pets kept at home for predicting the actual domestic expsoure to their specific allergens. Krakow inner city area study

Validity of the interview on pets kept at home for predicting the actual domestic expsoure to their specific allergens. Krakow inner city area study

Reduced late asthmatic response by repeated low-dose allergen exposure

Health hazard evaluation report: evaluation of indoor environmental quality at an accounting office, Florida.

Contact Info

Product

Resources

About