Dome epithelium and follicle‐associated basal lamina pores in the avian bursa of fabricius

Davenport, William D.; Allen, E. Raworth

doi:10.1002/ar.1092410203

Cited by 11 publications

(9 citation statements)

References 17 publications

(16 reference statements)

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“…6D). Instead, the anti-chCATH-B1 peptide staining was found to be most heavily concentrated on the filamentous structures that form a basket-like network surrounding the basal and lateral surfaces of bursal M cells (30). These results indicate that, although chCATH-B1 is synthesized by the interfollicular secretory epithelial cells, the mature peptide must be transported to become deposited onto a fibrillar network lining the M cell basolateral surfaces; a likely route of transport is via M cell transcytosis before or after peptide cleavage from the preproprotein.…”

Section: Cellular Distribution Of Chcath-b1 Transcripts and Chcath-b1mentioning

confidence: 89%

Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway

Goitsuka

Chen

Benyon

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

105

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Mucosal epithelial M cells provide an efficient portal of entry for microorganisms. Initially defined by their irregular microvilli and abundant transcytotic channels in the avian bursa of Fabricius, M cells also are found in the lymphoid follicle-associated epithelium of the mammalian appendix, Peyer's patches, and other mucosal surfacelymphoid interfaces. We describe here a previously unrecognized cathelicidin gene in chickens, chCATH-B1, that is expressed exclusively in the epithelium of the bursa of Fabricius. Like the mature peptides of previously identified cathelicidins, the carboxyl-terminal peptide of chCATH-B1 has broad antimicrobial activity against Gram-positive and Gram-negative bacteria. chCATH-B1 expression is restricted to the secretory epithelial cell neighbors of the M cells, whereas its mature peptide is transported to become concentrated on the fibrillar network surrounding basolateral surfaces of the M cells that overlie the bursal lymphoid follicles. We conclude that chCATH-B1 is well placed to serve a protective antimicrobial role at the M cell gateway.antimicrobial peptides ͉ follicle-associated epithelium ͉ innate immunity ͉ bursa of Fabricius

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Section: Cellular Distribution Of Chcath-b1 Transcripts and Chcath-b1mentioning

confidence: 89%

Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway

Goitsuka

Chen

Benyon

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

105

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“…In some follicles of 6-month-old chickens, where the division in cortex and medulla was still visible, rare cortical cells were still positive for these enzymes. Azan-Mallory stain and the ATP-ase reaction pictured vessels only in the cortex and in the collagenous space between cortex and medulla, confirming the absence of vascularization of the medulla (Jolly, 1914;Ackerman and Knouff, 1959).This particular distribution was supposed to constitute a blood-bursa barrier (Davenport and Allen, 1995).…”

mentioning

confidence: 77%

“…The IFE was reactive to anti-cytokeratin antibody (Viamontes et al, 1989;Olah and Glick, 1992).The basal layer lining the IFE contained bursin (Viamontes et al, 1989;Otsubo et al, 2001).The origin of FAE cells is controversial. It has been reported that the FAE cells are epithelial cells (Schaffner et al, 1974a;Schaffner et al, 1974b;Davenport and Allen, 1995;Paramithiotis and Ratcliffe, 1996), which are positive (Viamontes et al, 1989), or weakly positive (Olah and Glick, 1992) to anti-cytokeratin antibodies. Other authors reported that they are mesenchymal cells (Dolfi et al, 1981;Lupetti et al, 1983Lupetti et al, , 1986Lupetti et al, 1990), that are negative to anti-cytokeratin .…”

Section: Plical Epitheliummentioning

confidence: 97%

“…The bursal microenvironment is constituted by the epithelium covering the bursal plicae, and is characterized by the follicle-associated-epithelium (FAE) covering the follicles, the inter-follicleepithelium (IFE) located between the follicles, the epithelial cell line separating the cortex from the medulla, and the reticular-epithelial cells and secretory-dendritic cells in the medulla (Frazier, 1974;Olah and Glick, 1981, 1987, 1995Glick, 1983Glick, , 1991Glick, , 1994Lupetti et al, 1983;Houssaint et al, 1986;Eerola et al, 1987;Betti, 1989;Boyd et al, 1990;Wilson and Boyd, 1990;Dolfi et al, 1990;Ciriaco et al, 1994;Davenport and Allen, 1995).…”

Section: T Is Well Established That the Bursa Of Fabriciusmentioning

confidence: 99%

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Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

Mazzone¹,

Aita²,

Gabrielli³

et al. 2009

Eur J Histochem

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The Bursa of Fabricius of 15 day, 1-, 3-, and 6 month-old adult chickens (White Leghorn strain) were studied by histological and histochemical staining, histoenzymatic reactions (LDH, SDH, α-GPDH, NAD, NADPH, Ca ++ -dependent ATP-ase, pH 8.5) and by anti-thymostimulin immunoreaction. Positive reactions for mucopolysaccharides and enzymatic activities were located in the epithelia of the follicles, i.e. in follicleassociated-epithelium (FAE), inter-follicle-epithelium (IFE) and in different epithelial compartments of cortical and medullary zones. Positive reaction for thymostimulin-like (TSlike) substance was restricted to FAE cells and weakly to the basal lamina of IFE. In 6-month-old chickens, the FAE cells disappeared; the phenomenon of bursal regression was evident, although not all the follicles were involved. In the few still normal follicles, the good reactivity to the enzymes tested suggests that residual physiological activity is still present, even if reduced. , 1621) is a primary lymphoid organ peculiar to birds. The bursa is responsible for the maturation and differentiation of B-lymphocytes to produce humoral immunological responses. The other primary lymphoid organ, the thymus, instead, is responsible for the maturation and differentiation of T-lymphocytes, leading to cellular immunological responses (Dent and Good, 1965;Schaffner et al., 1974a;Le Douarin et al., 1984).The structure of the bursa has been described both during the ontogenetic period (Jolly, 1911a(Jolly, , 1914Cordier, 1969;Edwards et al., 1975;Le Douarin et al., 1975;Le Douarin et al., 1976;Le Douarin et al., 1984;Ritter and Lebacq, 1977) and during the posthatching period up to its involution (Jolly, 1911b(Jolly, ,1914Mc Connachie and Ruth, 1973;Glick, 1974Glick, , 1983Bellamy and Mohamed, 1982;Davenport and Allen, 1985).Since the discovery that the bursa was implicated in the differentiation of B-lymphocytes for humoral immunity (Chang et al., 1955;Glick et al., 1956;Papermaster and Good, 1962;Peterson and Good, 1965), attention was focused, on the one hand, on lymphoid cell populations (Ackermann and Knouff, 1959;Ackermann, 1962;Woods and Linna, 1965;Cooper et al., 1966; Toivanen et al., 1972 a,b;Toivanen et al., 1974;Back et al., 1973;Grossi et al., 1974;Grossi et al., 1976;Glick, 1974Glick, , 1983Glick, , 1995Glick et al., 1975;Eerola et al., 1982;Brand et al., 1983;Pink et al., 1985;Lassila, 1989;Nowak et al., 1990;Motyka and Reynolds, 1991;Petrini et al., 1991;Paramithiotis and Ratcliffe, 1993, 1994 a,b, 1996Reynaud and Weill, 1993;Masteller and Thompson, 1994;Masteller et al., 1995;Paramithiotis et al., 1995;Obranovich and Boyd, 1996;Funk and Thompson, 1996) and, on the other hand, on the epithelial stroma providing the bursal microenvironment within which B-cell maturation and differentiation occurs.

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“…It was reported that IFE has the features of a single layer of prismatic epithelium [23], while other authors [25,26] reported that it has features of pseudostratifi ed columnar epithelium. IFE has been proposed to have goblet cells in pigeons [18] and geese [24] and in the current study IFA is shown to be columnar in shape without goblet cells in the long-legged buzzard.…”

Section: Discussionmentioning

confidence: 99%

The Structure Of Bursa Of Fabricius In The Long-Legged Buzzard (Buteo Rufinus): Histological And Histochemical Study

et al. 2015

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The bursa of Fabricius (BF) is a lymphoepithelial organ found only in birds. Differences in morphology of BF could play an important role in immune response. The objective of this study was to investigate the histological and histochemical characteristics of the bursa of Fabricius in the long-legged buzzard (Buteo rufi nus). The material for the study comprised bursa samples obtained from three long-legged buzzards with permission of the General Directorate of Nature Protection and National Parks (Ankara, Turkey). Briefl y, interfollicular epithelium (IFE) was shown to be columnar in shape and not to contain goblet cells. Reticular fi bers were located in interfollicular septae. Each lymphoid follicle in the bursa of Fabricius in the long-legged buzzard was remarkably linked to the follicle associated epithelium (FAE). Namely, FAE has been reported to stimulate antibody production by transferring antigens to the medulla and have a leading role in developing of local immune response. Among the others, the speciesspecifi c differences in bursa of Fabricius morphology of long-legged buzzard (Buteo rufi nus) also might support the continuity of this species in nature.

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Dome epithelium and follicle‐associated basal lamina pores in the avian bursa of fabricius

Cited by 11 publications

References 17 publications

Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway

Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway

Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

The Structure Of Bursa Of Fabricius In The Long-Legged Buzzard (Buteo Rufinus): Histological And Histochemical Study

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