The nucleon(N )-Omega(Ω) system in the S-wave and spin-2 channel ( 5 S 2 ) is studied from the (2+1)-flavor lattice QCD with nearly physical quark masses (m π 146 MeV and m K 525 MeV). The time-dependent HAL QCD method is employed to convert the lattice QCD data of the two-baryon correlation function to the baryon-baryon potential and eventually to the scattering observables. The N Ω( 5 S 2 ) potential, obtained under the assumption that its couplings to the D-wave octet-baryon pairs are small, is found to be attractive in all distances and to produce a quasi-bound state near unitarity: In this channel, the scattering length, the effective range and the binding energy from QCD alone read a 0 = 5.30(0.44)( +0.16 −0.01 ) fm, r eff = 1.26(0.01)( +0.02 −0.01 ) fm, B = 1.54(0.30)( +0.04 −0.10 ) MeV, respectively. Including the extra Coulomb attraction, the binding energy of pΩ − ( 5 S 2 ) becomes B pΩ − = 2.46(0.34)( +0.04 −0.11 ) MeV. Such a spin-2 pΩ − state could be searched through two-particle correlations in p-p, p-nucleus and nucleus-nucleus collisions.