DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines

Glennon, Richard A.; Young, Richard; Jacyno, John M.; Slusher, Mark; Rosecrans, John A.

doi:10.1016/0014-2999(83)90196-6

Cited by 58 publications

(38 citation statements)

References 16 publications

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“…Based upon those reports and the previously described cross-generalization of hallucinogens in rats (Winter and Rabin, 1988;Glennon et al 1983), we would expect DPT to substitute for LSD, psilocybin and MDMA. The data of Figures 3 -5 only partially fulfill that prediction.…”

Section: Discussionmentioning

confidence: 76%

“…The discriminative stimulus properties of hallucinogens such as mescaline, DOI and LSD have been extensively investigated in several different animal species and it has been shown that, in agreement with studies in humans, these drugs generalize with one another (Winter, 1978;Glennon et al, 1983;Fiorella et al, 1995a). Furthermore, antagonist correlation analysis has determined that the stimulus effects of phenylisopropylamine and indolealkylamine hallucinogens are mediated by agonist activity at 5-HT 2A receptors (Fiorella et al, 1995b) and possibly modulated by agonist activity at 5-HT 2C (Fiorella et al, 1995c) and 5-HT 1A (Reissig et al, 2005) receptors.…”

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confidence: 88%

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Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents

Fantegrossi¹,

Reissig

Katz³

et al. 2008

Pharmacology Biochemistry and Behavior

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N,N-dipropyltryptamine (DPT) is a synthetic tryptamine hallucinogen which has been used psychotherapeutically in humans, but has been studied preclinically only rarely. In the present studies, DPT was tested in a drug-elicited head twitch assay in mice, and in rats trained to discriminate lysergic acid diethylamide (LSD), N,N-dimethyl-4-phosphoryloxytryptamine (psilocybin), or 3,4-methylenedioxymethamphetamine (MDMA). A separate group of rats was also trained to recognize DPT itself as a discriminative stimulus, and in all cases, the behavioral effects of DPT were challenged with the selective serotonin (5-HT) 2A antagonist M100907, the 5-HT 1A selective antagonist WAY-100635, or their combination. In the head twitch assay, DPT elicited dosedependent effects, producing a biphasic dose-effect curve. WAY-100635 produced a parallel rightward shift in the dose-effect curve for head twitches, indicative of surmountable antagonism, but the antagonist effects of M100907 were functionally insurmountable. DPT produced partial to full substitution when tested in rats trained to discriminate LSD, psilocybin or MDMA, and served as a discriminative stimulus. In all cases, the antagonist effects of M100907 were more profound than were those of WAY-100635. DPT is thus active in two rodent models relevant to 5-HT 2 agonist activity. The effectiveness with which M100907 antagonizes the behavioral actions of this compound strongly suggests that the 5-HT 2A receptor is an important site of action for DPT, but the modulatory actions of WAY-100635 also imply a 5-HT 1A -mediated component to the actions of this compound.

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 88%

Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents

Fantegrossi¹,

Reissig

Katz³

et al. 2008

Pharmacology Biochemistry and Behavior

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“…Because of these similarities, 5-MEO-DIPT likely binds to serotonin receptors, although if it binds to the serotonin transporter or other receptor systems is unknown. In support of this hypothesis, 5-MEO-DIPT has been shown to generalize to 1-(2,5-dimethoxy-4-methyphenyl)-2-aminopropane (Glennon et al, 1983), another Schedule I hallucinogen that binds to subtypes of the 5-HT 2 receptor (Eckler et al, 2003). The cataleptic states observed subsequent to 5-MEO-DIPT administration are also associated with 5-HT 2 agonists.…”

Section: Introductionmentioning

confidence: 86%

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

Williams

Herring

Schaefer

et al. 2006

Neuropsychopharmacol

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Many drugs are used or abused in social contexts without understanding the ramifications of their use. In this study, we examined the effects of a newly popular drug, 5-methoxy-diisopropyltryptamine (5-MEO-DIPT; 'foxy' or 'foxy-methoxy'). Two experiments were performed. In the first, 5-MEO-DIPT (0, 10, or 20 mg/kg) was administered to rats four times on a single day and animals were examined 3 days later. The animals that received 5-MEO-DIPT demonstrated hypothermia during the period of drug administration and delayed mild hyperthermic rebound for at least 48 h. Corticosterone levels in plasma were elevated in a dose-dependent manner compared to saline-treated animals with minor changes in 5-HT turnover and no changes in monoamine levels. In experiment 2, rats were examined in behavioral tasks following either 0 or 20 mg/kg of 5-MEO-DIPT. The animals treated with 5-MEO-DIPT showed hypoactivity and an attenuated response to ( + )-methamphetamine-induced stimulation (1 mg/kg). In a test of path integration (Cincinnati water maze), 5-MEO-DIPT-treated animals displayed deficits in performance compared to the saline-treated animals. No differences were noted in the ability of the animals to perform in the Morris water maze or on tests of novel object or place recognition. The data demonstrate that 5-MEO-DIPT alters the ability of an animal to perform certain cognitive tasks, while leaving others intact and disrupts the endocrine system. 5-MEO-DIPT may have the potential to induce untoward effects in humans.

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“…The lower lip retraction produced by 5-MeO-DMT, however, is thought to be due to the activation of 5-HT 1A rather than 5-HT 2 receptors because it is only produced by 5-HT 1A agonists, such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (Berendsen et al 1989). In tests of drug discrimination, 5-MeO-DMT was shown to generalize to other hallucinogens, such as LSD, DOM, DMT, and mescaline (Glennon et al 1979(Glennon et al , 1980(Glennon et al , 1983Spencer et al 1987). This fact is not surprising because 5-MeO-DMT has demonstrated agonist activity for the 5-HT 2 receptors most commonly associated with hallucinogenic activity (Boulenguez et al 1991;Dumuis et al 1987;Glennon et al 1980Glennon et al , 1984McClue et al 1989;McKenna et al 1990;Titeler et al 1988).…”

Section: Introductionmentioning

confidence: 97%

The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats

et al. 2006

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DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines

Cited by 58 publications

References 16 publications

Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents

Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats

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