Dolutegravir and Folic Acid Interaction during Neural System Development in Zebrafish Embryos
Daniela Zizioli,
Eugenia Quiros-Roldan,
Sara Ferretti
et al.
Abstract:Dolutegravir (DTG) is one of the most prescribed antiretroviral drugs for treating people with HIV infection, including women of child-bearing potential or pregnant. Nonetheless, neuropsychiatric symptoms are frequently reported. Early reports suggested that, probably in relation to folic acid (FA) shortage, DTG may induce neural tube defects in infants born to women taking the drug during pregnancy. Subsequent reports did not definitively confirm these findings. Recent studies in animal models have highlighte… Show more
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