Dolasetron und „shivering“

Böck, Matthias; Bauer, Martin; Rösler, L.; Sinner, Barbara; Motsch, J.

doi:10.1007/s00101-006-1099-z

Cited by 3 publications

(2 citation statements)

References 36 publications

(33 reference statements)

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“…A total of 121 studies were excluded because they were duplicates, obviously irrelevant trials, or did not meet the selection criteria of this analysis after reviewing the titles and abstracts. Subsequently, we carefully reviewed 26 potentially eligible articles, and 10 articles were excluded, 1 for conference abstract without full text, 16 1 for non-English study, 17 2 for investigating the therapeutic effect of 5-HT 3 RAs on established shivering, 18,19 1 for retraction article, 20 2 for letters to editors, 21,22 1 for lack of detailed information about methods of body temperature monitoring, 23 1 for with no grading or defi-nition of perioperative shivering, 24 and 1 for lack of the full texts despite contacting the authors. 25 Finally, 16 studies were included in the meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Wang

Song

Wang

et al. 2016

The Journal of Clinical Pharma

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The aim of this meta-analysis was to evaluate the preventive efficacy and safety of 5-HT receptor antagonists (5-HT RAs) on perioperative shivering. Relevant databases were searched to identify eligible randomized, controlled trials through January 2016. Primary outcome was the incidence of perioperative shivering, and secondary outcomes were the incidence of safety-related outcomes including postoperative nausea and vomiting (PONV), bradycardia, and hypotension. We calculated risk ratios (RRs) with 95% confidence intervals (CIs) for dichotomous data. Trial sequential analysis was performed to assess the risk of random errors and calculate the required information size. Sixteen studies with a total of 1126 patients were included in the meta-analysis. Compared with the control group, 5-HT RAs administered intravenously could statistically significantly reduce the incidence of perioperative shivering (RR, 0.44; 95%CI, 0.35 to 0.56; P < .00001; heterogeneity: I = 30%) as well as PONV (RR, 0.52; 95%CI, 0.28 to 0.97; P = .04; heterogeneity: I = 0%). However, they did not show superiority in lowering the rate of bradycardia (RR, 0.75; 95%CI, 0.38 to 1.49; P = 0.42; heterogeneity: I = 0%) or hypotension (RR, 0.79; 95%CI, 0.44 to 1.43; P = .44; heterogeneity: I = 24%). Trial sequential analysis of primary outcome showed that the required information size was 2634 patients and that the trial sequential monitoring boundary was crossed. Thus, more high-quality randomized, controlled trials with larger sample sizes are still required to draw a definite conclusion about the preventive efficacy of 5-HT RAs on perioperative shivering prevention in the future.

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Section: Study Selectionmentioning

confidence: 99%

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Wang

Song

Wang

et al. 2016

The Journal of Clinical Pharma

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“…The gold standard for treatment and prevention has not yet been defined. A variety of pharmacological treatments and methods to reduce postoperative shivering have been used including meperidine, alfentanil, tramadol, magnesium sulfate, ondansetron, dolasetron, and dexmedetomidine [5–9]. Ketamine has also been used as an anti-shivering drug.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of prophylactic use of ketamine for prevention of postanesthetic shivering: a systematic review and meta analysis

et al. 2019

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BackgroundPostanesthetic shivering is a common complication of anesthesia, which accounts for much discomfort in postoperative patients and may increase postoperative complications in high-risk patients. Due to the lack of high-quality evidence, it is difficult to draw a conclusion about optimal anti-shivering medication. The main purpose of this meta-analysis was to analyze and evaluate the efficacy and safety of prophylactic use of ketamine for preventing postanesthetic shivering.MethodsWe searched the following databases: Medline, Embase, and the Cochrane Central Register of Controlled Trails for randomized controlled trials. The primary outcome observed was the difference of the incidence rate of postanesthetic shivering between ketamine group and placebo group. The secondary outcomes were the sedation score and incidence of the side effects caused by ketamine and any other drugs utilized in the studies.ResultsIn this meta-analysis, we analyzed a total of 16 trials including 1485 patients. Ketamine reduced the incidence rate of postanesthetic shivering compared to a placebo (odds ratio [OR]: 0.13, 95% confidence interval [CI]: 0.06 to 0.26, P<0.01). Regarding side effects, there was no evident variability of the incidence of nausea and vomiting. Usage of ketamine was associated with a lower rate of hypotension and bradycardia when compared to a placebo. Hallucinations were more frequently observed in patients who received higher doses of ketamine. No significant difference was found in the incidence of postanesthetic shivering with ketamine versus other pharmacological interventions.ConclusionsKetamine can prevent postanesthetic shivering without severe side effects. However, ketamine shows no advantage over other anti-shivering drugs.

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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Weibel

Rücker

Eberhart

et al. 2020

Cochrane Database of Systematic Reviews

111

133

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Dolasetron und „shivering“

Abstract: The optimization of the clinical process and medical quality induced by a prophylaxis against shivering and postoperative nausea and vomiting compensates for the increased use of pharmaceutical resources in our setting.

Cited by 3 publications

References 36 publications

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Efficacy and safety of prophylactic use of ketamine for prevention of postanesthetic shivering: a systematic review and meta analysis

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

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Dolasetron und „shivering“

Abstract: The optimization of the clinical process and medical quality induced by a prophylaxis against shivering and postoperative nausea and vomiting compensates for the increased use of pharmaceutical resources in our setting.

Cited by 3 publications

References 36 publications

5‐HT3Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

5‐HT3Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Efficacy and safety of prophylactic use of ketamine for prevention of postanesthetic shivering: a systematic review and meta analysis

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

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5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis