Doing Knowledge. Neue Formen der Wissensorganisation durch den Einsatz neuer Medien

Ahrens, Daniela; Gerhard, Anette

doi:10.5771/1615-634x-2002--77

Cited by 1 publication

(1 citation statement)

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“…In general, barrier disruption causes increased expression of AMPs (hBD-2, hBD-3, LL-37, psoriasin) in both non-lesional AD skin and healthy skin (Table 3) (58,79). A similar response is seen in animal studies with increased AMP expression after tape stripping, which was reduced by occlusion (80). Interestingly, upregulation of hBD-2, hBD-3 and psoriasin mRNA in non-lesional skin after skin barrier disruption (tape stripping) shows a similar response in AD and psoriasis (79), indicating that non-lesional AD skin has the same capacity as non-lesional psoriatic skin for producing AMPs when induced by barrier disruption alone.…”

Section: Skin Barrier Disruptionsupporting

confidence: 59%

In vivo expression of antimicrobial peptides in atopic dermatitis

Clausen

Slotved

Krogfelt

et al. 2015

Experimental Dermatology

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The aim of this review is to present findings on expression of antimicrobial peptides (AMPs) in atopic dermatitis (AD) skin, focusing only on in vivo studies, and to discuss differences in results obtained using various skin sampling techniques and different methodology for analysis of AMPs. The review also includes a discussion of the effect of frequently used treatments on AMP expression. Many studies have shown a reduced level of AMPs in lesional AD skin when compared to psoriatic skin, explaining the high frequency of AD-related infections. Interestingly, however, non-lesional AD skin has shown the same upregulation of AMPs after barrier disruption as nonlesional psoriatic skin. Various methods have been used to analyse AMP expression in the skin, and when comparing these methods, differences are revealed in AMP expression depending on the method used for sampling and analysis. Comparisons indicate that analyses of mRNA levels of AMPs may find greater differences in expression than analyses of protein levels. Few studies evaluate the effect of topical treatments on the expression of AMPs, and these indicate an inhibition of AMP expression, particularly after use of corticosteroids. AMPs are important components of the skin as a defense against infections, and despite much research, the clinical importance of the effect of common treatments, including systemic treatments for AD and the interplay between AMPs and the skin microbiome, is still largely unknown.

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Section: Skin Barrier Disruptionsupporting

confidence: 59%