Dogs: Active Role Model for Cancer Studies—A Review

Hawai, Sana Munaf; Al-Zayer, Maryam; Ali, M. M.; Niu, Yuanjie; Alawad, Awad Ali M.; Aljofan, Mohamad; Aljarbou, Ahmed N.; Altuwaijri, Saleh

doi:10.4236/jct.2013.45113

Cited by 8 publications

(6 citation statements)

References 58 publications

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“…However, the proximity between canine and human species has encouraged scientist to introduce dogs as an alternative model for comparative cancer research projects. Hawai et al (2013) and Sultan and Ganaie (2018) have reviewed many factors in favor of adopting dogs. These included a homologous genome sequence, genetic diversity, spontaneous growth of tumors, common living environment and many others.…”

Section: Introductionmentioning

confidence: 99%

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Al-Mansour¹,

Kubba²,

Al-Azreg³

et al. 2018

Open Vet J.

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This study aimed at establishing aspects of comparison between canine and human mammary gland tumors. In order to achieve that, 44 specimens of canine mammary tumors and 70 specimens of human breast tumors were examined in order to state points of similarity in morphology, cells of origin, behavior and existence of tissue markers. We found that the ratio of benign to malignant forms was 4.5% to 95.5% in canine samples and 45.7% to 54.3% in human samples. In both species, malignant tumors composed of infiltrating ductal cells were in the forefront despite dissimilarity in nomenclature. Other kinds of lower rate of existence included, invasive micro-papillary carcinoma, mucinous carcinoma and invasive comedo-carcinoma which have displayed similar morphology and terminology in both species. Chondroid and squamous differentiation were found in human and canine specimens. In human samples, fibro-adenoma mounted up to 30 out of 32 benign tumors (93.8%). Her-2 and Ki-67 were detected in the specimens of both species but ER was detected in human specimens only. Our findings suggest a significant degree of resemblance between certain mammary tumor in canine and human. Such findings are in support of employing dogs in research investigation for human mammary tumors.

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Section: Introductionmentioning

confidence: 99%

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Al-Mansour¹,

Kubba²,

Al-Azreg³

et al. 2018

Open Vet J.

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“…The reaction of tumoral stroma may be related to tumor progression and metastasis. Canine mammary tumors are strikingly similar to human mammary tumors (Hawai et al, 2013). The current study found that stromal reactions of the tumors should be evaluated for malignancy.…”

Section: Discussionmentioning

confidence: 55%

Immunohistochemical Analysis of Na+/K+-ATPase and Bone Morphogenetic Protein-2 Expressions in Both Parenchymal and Stromal Cells from Benign and Malignant Canine Mammary Tumors

Özmen¹

2021

Preprint

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Canine mammary tumors are the most common type of dog tumor, and they are similar to human breast tumors. Na+/K+-ATPase is a common plasma membrane ion pump with important physiological and pathophysiological functions. In mammary tumors, the tumor microenvironment was composed of a heterogeneous population of tumor cells and nearby endogenous stromal cells. Bone morphogenetic proteins (BMPs) regulate fetal development, tissue homeostasis and differentiation, and a variety of cellular functions. The purpose of this study is to examine the immunohistochemical expression of Na+/K+-ATPase and BMP-2 in tumoral and stromal cells from benign and malignant canine mammary tumors. In this study, ten benign and ten malignant mammary tumors from the archives of the Department of Pathology were used, with five normal breast tissues serving as controls. The results of the revealed that tumors had higher levels of Na+/K+-ATPase and BMP-2 expressions than normal mammary tissue. While both markers were expressed negatively or mildly in benign tumors, they increased significantly in malignant tumors. Both Na+/K+-ATPase and BMP-2 are expressed by tumoral and stromal cells in canine mammary tumors. When compared to compared to BMP-2, Na+/K+-ATPase expression was found to be more severe. This study found that Na+/K+-ATPase and BMP-2 can be used as markers of malignancy in canine mammary tumors and that stromal cells also play an important role in tumor progression. These findings also indicated that Na+/K+-ATPase and BMP-2 may be used for early diagnosis or as a potential target for treatment of canine and human breast tumors in the future.

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“…Spontaneous cancer in pet dogs is considered an attractive model to study the efficacy of drug candidates for cancer therapy (Rowell, McCarthy, & Alvarez, 2011). Cancers in affective animals such as pet dogs are characterized by histological features similar to human cancer,tumour growth over long periods, inter‐individual and intra‐tumour heterogeneity, the development of recurrent or resistant diseases and metastasis to relevant distal sites (Hawai et al, 2013). Based on that, we evaluated the safety, tolerability and antineoplastic effect of CIGB‐552 in tumour‐presenting dogs.…”

Section: Cigb‐552 Has Antitumour Effects In Vitro and In Vivomentioning

confidence: 99%

Antitumour peptide based on a protein derived from the horseshoe crab: CIGB‐552 a promising candidate for cancer therapy

Arguelles

Riera‐Romo²,

Vallespí

2020

British J Pharmacology

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Peptide‐based cancer therapy has been of great interest due to the unique advantages of peptides, such as their low MW, the ability to specifically target tumour cells, easily available and low toxicity in normal tissues. Therefore, identifying and synthesizing novel peptides could provide a promising option for cancer patients. The antitumour second generation peptide, CIGB‐552 has been developed as a candidate for cancer therapy. Proteomic and genomic studies have identified the intracellular protein COMMD1 as the specific target of CIGB‐552. This peptide penetrates to the inside tumour cells to induce the proteasomal degradation of RelA, causing the termination of NF‐κB signalling. The antitumour activity of CIGB‐552 has been validated in vitro in different human cancer cell lines, as well as in vivo in syngeneic and xenograft tumour mouse models and in dogs with different types of cancers. The aim of this review is to present and discuss the experimental data obtained on the action of CIGB‐552, including its mechanism of action and its therapeutic potential in human chronic diseases. This peptide is already in phase I clinical trials as antineoplastic drug and has also possible application for other inflammatory and metabolic conditions.

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Dogs: Active Role Model for Cancer Studies—A Review

Cited by 8 publications

References 58 publications

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Immunohistochemical Analysis of Na+/K+-ATPase and Bone Morphogenetic Protein-2 Expressions in Both Parenchymal and Stromal Cells from Benign and Malignant Canine Mammary Tumors

Antitumour peptide based on a protein derived from the horseshoe crab: CIGB‐552 a promising candidate for cancer therapy

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