DogMap: an international collaboration toward a low-resolution canine genetic marker map

Dolf, G.

doi:10.1093/jhered/90.1.3

Cited by 8 publications

(2 citation statements)

References 36 publications

(26 reference statements)

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“…The current linkage map is built upon the success of previous efforts (Lingaas et al 1997;Mellersh et al 1997;Dolf 1999;Langston et al 1999;Neff et al 1999); however, those maps were constructed with ,600 markers and lack the coverage, precision, and accuracy needed to optimize linkage analysis and subserve LD mapping (Dukes-McEwan and Jackson 2002). A comprehensive map would enhance genetic analysis in several ways.…”

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confidence: 99%

A Comprehensive Linkage Map of the Dog Genome

et al. 2010

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We have leveraged the reference sequence of a boxer to construct the first complete linkage map for the domestic dog. The new map improves access to the dog's unique biology, from human disease counterparts to fascinating evolutionary adaptations. The map was constructed with $3000 microsatellite markers developed from the reference sequence. Familial resources afforded 450 mostly phase-known meioses for map assembly. The genotype data supported a framework map with $1500 loci. An additional $1500 markers served as map validators, contributing modestly to estimates of recombination rate but supporting the framework content. Data from $22,000 SNPs informing on a subset of meioses supported map integrity. The sex-averaged map extended 21 M and revealed marked region-and sex-specific differences in recombination rate. The map will enable empiric coverage estimates and multipoint linkage analysis. Knowledge of the variation in recombination rate will also inform on genomewide patterns of linkage disequilibrium (LD), and thus benefit association, selective sweep, and phylogenetic mapping approaches. The computational and wet-bench strategies can be applied to the reference genome of any nonmodel organism to assemble a de novo linkage map.

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confidence: 99%

A Comprehensive Linkage Map of the Dog Genome

et al. 2010

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“…Knowledge of the molecular background of a broad range of hereditary canine diseases was developed on the basis of extensive studies of the dog genome, which begin in 1993 during the First International DogMap Meeting in Oslo, Norway (Report from the First International DogMap Meeting 1993). The main goals of this international collaboration were to establish linkage and cytogenetic (mainly based on microsatellites) marker maps of the dog genome (Dolf et al 1999, Switonski et al 2004. The next step was genome sequencing of the dog, initially among domestic mammals (Kirkness et al 2003, Lindblad-Toh et al 2005.…”

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confidence: 99%

Impact of gene therapy for canine monogenic diseases on the progress of preclinical studies

Świtoński

2020

J Appl Genetics

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Rapid progress in knowledge of the organization of the dog genome has facilitated the identification of the mutations responsible for numerous monogenic diseases, which usually present a breed-specific distribution. The majority of these diseases have clinical and molecular counterparts in humans. The affected dogs have thus become valuable models for preclinical studies of gene therapy for problems such as eye diseases, immunodeficiency, lysosomal storage diseases, hemophilia, and muscular dystrophy. Successful gene therapies in dogs have significantly contributed to decisions to run clinical trials for several human diseases, such as Leber's congenital amaurosis 2-LCA2 (caused by a mutation of RPE65), X-linked retinitis pigmentosa-XLRP (caused by mutation RPGR), and achromatopsia (caused by mutation of CNGB3). Promising results were also obtained for canine as follows: hemophilia (A and B), mucopolysaccharidoses (MPS I, MPS IIIB, MPS VII), leukocyte adhesion deficiency (CLAD), and muscular dystrophy (a counterpart of human Duchenne dystrophy). Present knowledge on molecular background of canine monogenic diseases and their successful gene therapies prove that dogs have an important contribution to preclinical studies.

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Comparing the Human and Canine Genomes

Świtoński¹,

Szczerbal²

2008

Encyclopedia of Life Sciences

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The dog is a unique species due to its phenotypic variability, exceptional among mammals. From the point of view of comparative biomedicine it needs to be emphasized that in numerous breeds specific hereditary diseases occur with high prevalence and many of them have molecular and clinical counterparts in humans. Thus, the dog is a very useful model to study human hereditary diseases and their therapy, including gene therapy. Knowledge on the human and dog genomes is very advanced. Both genomes were sequenced, their high‐density marker genome maps are available and evolutionary conserved segments (CSs) were identified by comparative chromosome painting, marker genome mapping and sequencing.

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DogMap: an international collaboration toward a low-resolution canine genetic marker map

Cited by 8 publications

References 36 publications

A Comprehensive Linkage Map of the Dog Genome

A Comprehensive Linkage Map of the Dog Genome

Impact of gene therapy for canine monogenic diseases on the progress of preclinical studies

Comparing the Human and Canine Genomes

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