DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature

Koufopoulos, Nektarios; Damaskou, Vasileia; Siozopoulou, Vasiliki; Kokoropoulos, Panagiotis; Gouloumis, Alina-Roxani; Arkadopoulos, Nikolaos; Panayiotides, Ioannis G.

doi:10.7759/cureus.25263

Cited by 1 publication

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References 23 publications

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“…A primary mesenteric leiomyosarcoma even diffusely expresses DOG1, while lacking of CD117 immunopositivity. 21 GISTs usually focally express SMA and desmin. Diffuse expression of SMA and desmin can help to differentiate DOG1 positive smooth muscle tumors from CD117 negative GISTs.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid Subtype Gastrointestinal Stromal Tumors of Stomach in an Endoscopic Biopsy: A Potential Diagnostic Pitfall

Xu,

Tang,

Chen

et al. 2023

OTT

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Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract with a broad morphological spectrum. Although epithelioid GISTs account for 20% of GISTs, their morphological features may pose a diagnostic pitfall for pathologists due to their morphological similarities to poorly differentiated adenocarcinoma and lymphoma. Case Presentation: Herein, we report a 65-year-old male patient with gastric epithelioid GIST misdiagnosed as adenocarcinoma for four years. During this period, he was treated with chemotherapy combined with PD-L1 immunotherapy. The clinicians thought the treatments were effective. However, there was no significant change in tumor size. The patient's clinical symptoms did not improve significantly as well. Finally, an endoscopic biopsy was performed again and gastric epithelioid GIST was confirmed in our hospital through morphology, immunohistochemistry, and whole-genome sequencing. Conclusion: A broad morphological spectrum and diverse immunophenotypic changes of GISTs could represent a pitfall for pathologists. However, predisposed anatomical sites, morphology, and corresponding immunohistochemical markers are of great significance for the diagnosis of GISTs and the differential diagnosis from other diseases. On the other hand, clinicians should diagnose and comprehensively evaluate treatment effects based on the patient's clinical symptoms and relevant laboratory examinations, instead of over-reliance on pathological diagnosis.

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Section: Discussionmentioning

confidence: 99%