Dog and mouse: toward a balanced view of the mammalian olfactory system

Barrios, Arthur W.; Sánchez‐Quinteiro, Pablo; Salazar, Ignacio

doi:10.3389/fnana.2014.00106

Cited by 33 publications

(41 citation statements)

References 45 publications

(56 reference statements)

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“…The lateral nasal meatus ( Meatus nasi lateralis ) is a longitudinal space located laterally to the middle nasal meatus and communicating directly with it. Finally, the nasopharyngeal meatus ( Meatus nasopharyngeus ) is the place where the four meatuses of each nasal cavity converge and continue to the choanae ( Choanae ), where the nasopharynx begins (Evans and De Lahunta, ; Barrios et al, ; Chamanza and Wright, ).…”

Section: General Macroscopic Anatomymentioning

confidence: 99%

The Nasal Cavity of the Rat and Mouse—Source of Mesenchymal Stem Cells for Treatment of Peripheral Nerve Injury

Alvites

Caseiro

Pedrosa

et al. 2018

The Anatomical Record

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The nasal cavity performs several crucial functions in mammals, including rodents, being involved in respiration, behavior, reproduction, and olfaction. Its anatomical structure is complex and divided into several regions, including the olfactory recess where the olfactory mucosa (OM) is located and where the capture and interaction with the environmental odorants occurs. Among the cells of this region are the OM mesenchymal stem cells (MSCs), whose location raises the possibility that these cells could be involved in the peculiar ability of the olfactory nerve to regenerate continuously throughout life, although this relationship has not yet been confirmed. These cells, like all MSCs, present functional characteristics that make them candidates in new therapies associated with regenerative medicine, namely to promote the regeneration of the peripheral nerve after injury. The availability of stem cells to be therapeutically applied essentially depends on their collection in the tissue of origin. In the case of mice and rat's OM-MSCs, knowledge about the anatomy and histology of their nasal cavity is essential in establishing effective collection protocols. The present article describes the morphological characteristics of rodent's OM and establishes an alternative protocol for access to the olfactory recess and collection of the OM. Anat Rec, 301:1678-1689, 2018. © 2018 Wiley Periodicals, Inc.

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Section: General Macroscopic Anatomymentioning

confidence: 99%

The Nasal Cavity of the Rat and Mouse—Source of Mesenchymal Stem Cells for Treatment of Peripheral Nerve Injury

Alvites

Caseiro

Pedrosa

et al. 2018

The Anatomical Record

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“…Although the SO has only been studied in depth in mouse and rat, there is evidence to suggest that the SO could have disappeared in some mammals and could be regressing in others (Weiler and Farbman, ). In our laboratory we have been unable to identify any structure alike the mouse SO in fetuses, newborn and adult specimens of cat, pig, sheep, and dog, data partially published (Barrios et al, ).…”

Section: Summary Of the Data Found In The Drawings/pictures Reported mentioning

confidence: 87%

“…It has been described in detail in certain rodents –mouse, rat, hamster and gerbil– displaying subtle differences between them (Brechbühl et al, ). In other groups of mammals its presence is very unclear and, as in the case of the SO, our attempts to identify the ganglion in domestic mammals were unsuccessful, data partially published (Barrios et al, ). Moreover, it looks like there are frequent misunderstandings regarding the presence of the GgG, since the original information provided by the most quoted reference thereon (Grüneberg, ) is not usually approached with the desirable objectivity.…”

Section: Summary Of the Data Found In The Drawings/pictures Reported mentioning

confidence: 98%

Revisiting the Vomeronasal System From an Integrated Perspective

Salazar

Barrios

Sánchez‐Quinteiro

2016

The Anatomical Record

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"Olfactory subsystems" is a relatively new terminology to refer to the different regions of the nasal cavity featuring olfactory sensory neurons. In mice, the olfactory chemical cues are detected in four well delimited areas: the main olfactory epithelium, the septal organ, Grüneberg's ganglion, and the sensory epithelium of the vomeronasal organ. Nevertheless, such distribution is by no means exhibited by all mammals. In microsmatic mammals -humans included- the only existing olfactory subsystem is the main olfactory epithelium. This raises the question of whether the lack of certain olfactory structures in those species implies that they are unable to identify certain olfactory signals, or on the contrary, their main olfactory epithelium assumes such role. It would be interesting to determine, in the context of biomedical research, if the sense of smell in humans is fully or partially endowed with the wide range of functions assigned to the vomeronasal system in mice. If it is not, presumptive implications of the lack of such functions should be addressed in human health and well-being. Anat Rec, 299:1488-1491, 2016. © 2016 Wiley Periodicals, Inc.

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“…The morphology of the OSbS as a whole has been addressed by Salazar's group in two articles. The first of them presents an on-line atlas of the murine nasal cavity, freely available at http://www.usc.es/anatembriol/ (Barrios et al, 2014a ); in the second, one of the most relevant results points out that the dog lacks two of the olfactory areas of the mouse, the SO and the GG (Barrios et al, 2014b ).…”

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confidence: 99%