Does Zika virus infection affect mosquito response to repellents?

Leal, Walter Soares; Barbosa, Rosângela Maria Rodrigues; Zeng, Fangfang; Faierstein, Gabriel B.; Tan, Kaiming; Paiva, Marcelo Henrique Santos; Guedes, Duschinka Ribeiro Duarte; Crespo, Mônica Maria; Ayres, Constância F. J.

doi:10.1038/srep42826

Cited by 29 publications

(45 citation statements)

References 33 publications

(39 reference statements)

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“…Lastly, we compared the repellency activity of the 5X homemade recipe with that of 1% DEET against the yellow fever mosquito, which carries dengue, ZIKA, chikungunya, and the yellow fever virus in Brazil. As previously reported, 17 protection elicited by 1% DEET is high, but not as high as protection against…”

Section: Odorant Receptor Sensitive To the Active Ingredient In Indiasupporting

confidence: 82%

“…We aimed at obtaining extracts with at least 10 mg of eugenol per ml, which is the minimal desired concentration (1%). In our surface landing and feeding assays, a dose of 1% is equivalent to approximately 6.3% dose when tested in the arm-in-cage assays 17 , which in turn is the most common dose of DEET-based repellents in the market. 17 Our analysis ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In our surface landing and feeding assays, a dose of 1% is equivalent to approximately 6.3% dose when tested in the arm-in-cage assays 17 , which in turn is the most common dose of DEET-based repellents in the market. 17 Our analysis ( Fig. 3) showed a time-dependent increase in the concentration of eugenol in the extracts from all brands.…”

Section: Resultsmentioning

confidence: 99%

“…First, we compared in our surface-landing and feeding assay 6,17 18 and the Environmental Protection Agency (EPA) 19 . The data show a significantly higher protection elicited by DEET than the 5X homemade repellent (n = 9, P = 0.0159, Mann-Whitney test) ( Fig.…”

Section: Quinquefasciatus Responses To An Improved Homemade Formumentioning

confidence: 99%

“…If young mosquitoes feed from an infected host, these mosquitoes are more likely to transmit in the next gonotrophic cycle, because there would be enough time for the virus to complete the extrinsic incubation period, ie, the time required for the virus to pass through the midgut barrier into the mosquito's hemocoel, invade the salivary glands, and replicate to a level that can be infective in the next blood meal 17 . To fend off these older mosquitoes even higher doses of repellents are required 17 . For example, it is recommended to use DEET at 20-30% for protection against infected mosquitoes 17 .…”

Section: Odorant Receptor Sensitive To the Active Ingredient In Indiamentioning

confidence: 99%

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A popular Indian clove-based mosquito repellent is a false economy

Tan

Faierstein

et al. 2019

Preprint

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Insect repellents are important prophylactic tools for travelers to and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases, and the first line of defense against emerging arboviruses. However, the cost of daily applications of even the most affordable and the gold standard of insect repellents, DEET, is still high for low-income populations where repellents are needed the most. An Indian clove-based homemade recipe has been presented as a panacea. We analyzed this homemade repellent and confirmed by behavioral measurements and odorant receptor responses that eugenol is the active ingredient in this formulation. Prepared as advertised, this homemade repellent is ineffective, whereas 5X more concentrated extracts from the brand most enriched in eugenol showed moderate repellency activity against Culex quinquefasciatus and Aedes aegypti. DEET showed higher performance when compared to the 5X concentrated formulation and is available in the same market at a lower price than the cost of the ingredients to prepare the homemade formulation.

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Section: Odorant Receptor Sensitive To the Active Ingredient In Indiasupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Quinquefasciatus Responses To An Improved Homemade Formumentioning

confidence: 99%

Section: Odorant Receptor Sensitive To the Active Ingredient In Indiamentioning

confidence: 99%

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A popular Indian clove-based mosquito repellent is a false economy

Tan

Faierstein

et al. 2019

Preprint

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Modulation of odour-guided behaviour in mosquitoes

Hill

2021

Cell Tissue Res

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Mosquitoes are emerging as model systems with which to study innate behaviours through neuroethology and functional genomics. Decades of work on these disease vectors have provided a solid behavioural framework describing the distinct repertoire of predominantly odour-mediated behaviours of female mosquitoes, and their dependence on life stage (intrinsic factors) and environmental cues (extrinsic factors). The purpose of this review is to provide an overview of how intrinsic factors, including adult maturation, age, nutritional status, and infection, affect the attraction to plants and feeding on plant fluids, host seeking, blood feeding, supplemental feeding behaviours, pre-oviposition behaviour, and oviposition in female mosquitoes. With the technological advancements in the recent two decades, we have gained a better understanding of which volatile organic compounds are used by mosquitoes to recognise and discriminate among various fitness-enhancing resources, and characterised their neural and molecular correlates. In this review, we present the state of the art of the peripheral olfactory system as described by the neural physiology, functional genomics, and genetics underlying the demonstrated changes in the behavioural repertoire in female mosquitoes. The review is meant as a summary introduction to the current conceptual thinking in the field.

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Impact of Zika virus for infertility specialists: current literature, guidelines, and resources

Dubaut

Higuita

Quaas

2017

J Assist Reprod Genet

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In the past 2 years, Zika virus has emerged from obscurity onto the world stage-traversing and transcending clinical specialties, basic science disciplines, and public health efforts. The spread of Zika virus has serious implications for the specialty of reproductive endocrinology and infertility. Our patients, practices, and labs-worldwide and specifically in the USA-have been impacted by this teratogenic, sexually transmitted, largely asymptomatic virus. While the World Health Organization's Public Emergency of International Concern designation has lapsed as major epidemics have subsided and understanding of risks is in part clarified, the acute and long-term threat to pregnant patients is not over. The risk of wider spread in the USA is not insignificant, the subtler and long-ranging consequences beyond microcephaly are not fully known, large geographic areas of risk still contain naïve populations, and whether Zika will continue to be an intermittent risk in endemic areas is uncertain. Staying up to date with the burgeoning research on Zika virus is an important objective for the infertility specialist. Here, we review in detail the most relevant recent developments, discuss applicable guidelines, and propose strategies for contributing to a reduction in the risk and burden of Zika virus.

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Does Zika virus infection affect mosquito response to repellents?

Cited by 29 publications

References 33 publications

A popular Indian clove-based mosquito repellent is a false economy

A popular Indian clove-based mosquito repellent is a false economy

Modulation of odour-guided behaviour in mosquitoes

Impact of Zika virus for infertility specialists: current literature, guidelines, and resources

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