Does wound pH modulation with 3% citric acid solution dressing help in wound healing: A pilot study

Prabhu, Vinod; Prasadi, Sadanand; Pawar, Vishrabdha; Shivani, Aslam; Gore, Alka Dilip

doi:10.4103/2320-3846.140690

Cited by 10 publications

(12 citation statements)

References 2 publications

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“…On histopathological examination, they also found that wounds treated with citric acid showed an increase in fibroblasts and granulation tissue on 7 th day. [21] In the current study, the average increase in percentage of granulation area was more when 3% citric acid was used for dressing (65.36%) than that in control group (60.60%). The difference seen in both the groups was statistically significant (p value-0.044) by 12 th day.…”

Section: Discussionmentioning

confidence: 43%

Evaluation of effect of topical application of 3% citric acid on wound healing

2017

Int. J. Curr. Res. Med. Sci.

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Background-Wound healing is a complex process influenced by multiple factors. This study looks for the efficacy of 3% citric acid as pH modifying dressing when compared to conventional method. The pH within the wound milieu indirectly and directly affects the various biochemical reactions in the wound healing. Materials and methods-An unicentric, prospective , randomised study with a parallel design was used to compare patients treated with conventional dressing and with 3% citric acid respectively. The wounds were examined for 14 days and parameters of healing were evaluated. The results were analysed using chi-square test and unpaired t-test. Results-Use of citric acid made the wound surface acidic (4-6). Patients treated with citric acid (72.06%) showed more reduction in wound size than those who were treated by conventional method (67.40%). The increase in granulation area was more when citric acid (65.36%) was used than that in control group (60.60%). Wounds treated with citric acid showed early reduction in amount of discharge as compared to control group. The mean hospital stay of patients in citric acid group (7.74 days) was comparatively less than that of patients in control group (10.38 days). Conclusion-3% citric acid is safe and effective in all types of wound management. It acts by reducing pH of wound surface and inhibits bacterial proliferation. It aids in early healing by promoting formation of healthy granulation tissue.

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Section: Discussionmentioning

confidence: 43%

Evaluation of effect of topical application of 3% citric acid on wound healing

2017

Int. J. Curr. Res. Med. Sci.

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“…used 3% citric acid for topical application in 25 patients and a remarkable reduction in wound size (82.01%) was noted. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…found that the wound environment was acidic (4–6) when citric acid was used for topical dressings. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Comparison of effect of pH modulation on wound healing with topical application of citric acid versus superoxide ions

et al. 2020

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“…, endotoxins and metalloproteinases), altering protease activity, etc. Microbiological evaluation after application of citric acid shows significant reductions in bacterial counts, or no growth, suggesting that citric acid effectively controls the infection[ 13 , 76 - 79 ].…”

Section: Specific Roles Of Acidsmentioning

confidence: 99%

Role of an acidic environment in the treatment of diabetic foot infections: A review

Nagoba

Gavkare

Rayate

et al. 2021

WJD

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Management of diabetic foot ulcers is the biggest challenge to the clinician, as conventional antibiotic therapies and local wound care have their own limitations. They are not effective for control of infections and promotion of healing because of cytotoxic effects. In view of cytotoxicity of routinely used topical antiseptic agents, this article focuses on the search of an ideal topical antiseptic agent that is safe and effective in controlling infectious agents and also in promoting the healing process. This review focuses on the use of various acids such as citric, acetic, hyaluronic, and hypochlorous acids as topical agents in diabetic foot infections. This article also focuses on the different roles of acids in the treatment of diabetic foot infections.

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Does wound pH modulation with 3% citric acid solution dressing help in wound healing: A pilot study

Cited by 10 publications

References 2 publications

Evaluation of effect of topical application of 3% citric acid on wound healing

Evaluation of effect of topical application of 3% citric acid on wound healing

Comparison of effect of pH modulation on wound healing with topical application of citric acid versus superoxide ions

Role of an acidic environment in the treatment of diabetic foot infections: A review

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