Abstract:SummaryThis systematic review assessed the effect of weight loss in overweight and/or obese women undergoing assisted reproductive technology (ART) on their subsequent pregnancy outcome. Weight losses achieved by diet and lifestyle changes, very--low--energy diets, non--surgical medical interventions and bariatric surgery translated into significantly increased pregnancy rates and/or live birth in overweight and/or obese women undergoing ART in 8 of the 11 studies reviewed. In addition, regularization of the m… Show more
“…One small study suggested that there was no improvement in overall sexual function after LAGB in males and that erectile index and orgasmic function worsened when adjusted for time (164). The evidence supporting an effect of weight loss on the management of fertility issues is of relative low quality, but the overall results suggest a benefit (192). Studies to evaluate the effect of bariatric surgery on male fertility are needed (139).…”
Section: Effect Of Sustained Weight Loss On Fertility/pregnancymentioning
Obesity is a chronic and complex medical condition associated with a large number of complications affecting most organs and systems through multiple pathways. Strategies for weight management include behavioral, pharmacological, and surgical interventions, all of which can result in a reduction in obesity-related comorbidities and improvements in quality of life. However, subsequent weight regain often reduces the durability of these improvements. The objective of this article is to review evidence supporting the long-term effects of intentional weight loss on morbidity, mortality, quality of life, and health-care cost. Overall, considerable evidence suggests that intentional weight loss is associated with clinically relevant benefits for the majority of obesity-related comorbidities. However, the degree of weight loss that must be achieved and sustained to reap these benefits varies widely between comorbidities.
“…One small study suggested that there was no improvement in overall sexual function after LAGB in males and that erectile index and orgasmic function worsened when adjusted for time (164). The evidence supporting an effect of weight loss on the management of fertility issues is of relative low quality, but the overall results suggest a benefit (192). Studies to evaluate the effect of bariatric surgery on male fertility are needed (139).…”
Section: Effect Of Sustained Weight Loss On Fertility/pregnancymentioning
Obesity is a chronic and complex medical condition associated with a large number of complications affecting most organs and systems through multiple pathways. Strategies for weight management include behavioral, pharmacological, and surgical interventions, all of which can result in a reduction in obesity-related comorbidities and improvements in quality of life. However, subsequent weight regain often reduces the durability of these improvements. The objective of this article is to review evidence supporting the long-term effects of intentional weight loss on morbidity, mortality, quality of life, and health-care cost. Overall, considerable evidence suggests that intentional weight loss is associated with clinically relevant benefits for the majority of obesity-related comorbidities. However, the degree of weight loss that must be achieved and sustained to reap these benefits varies widely between comorbidities.
“…Preconception weight loss in obese women is also important to reduce morbidity from anesthesia-related surgical procedures, such as oocyte retrieval (124). To date, however, there is no strong evidence that preconception weight loss in women improves IVF-related pregnancy outcome (125), and the data are less clear in men. Nevertheless, weight loss is assumed to benefit fertility as it does for diabetes and CVD.…”
The purpose of this ASRM Practice Committee report is to provide clinicians with principles and strategies for the evaluation and treatment of couples with infertility associated with obesity. This revised document replaces the Practice Committee document titled, "Obesity and reproduction: an educational bulletin," last published in 2008 (Fertil Steril 2008;90:S21-9).
“…Several studies demonstrate the benefit of weight loss as part of a structured weight loss program upon the chance of conception for overweight women, and also as part of their IVF treatment (61,314). In a systematic review of 11 stud-ies that met the search criteria weight loss on the outcome of subsequent IVF treatment, losing weight by either diet and lifestyle changes (7 studies), nonsurgical medical interventions (1 study), or bariatric surgery (2 studies) led to a significant increase in the natural conception rate, an increase in the number of embryos available for transfer as well as the subsequent pregnancy rate, and a decrease in the miscarriage rate (314).…”
Section: Obesitymentioning
confidence: 99%
“…In a systematic review of 11 stud-ies that met the search criteria weight loss on the outcome of subsequent IVF treatment, losing weight by either diet and lifestyle changes (7 studies), nonsurgical medical interventions (1 study), or bariatric surgery (2 studies) led to a significant increase in the natural conception rate, an increase in the number of embryos available for transfer as well as the subsequent pregnancy rate, and a decrease in the miscarriage rate (314). Due to the difficulty in completing such studies, the overall quality of the studies was reported as weak, although all interventions led to significant improvements in pregnancy or live birth rates in overweight or obese women, with several studies reporting an improvement in spontaneous pregnancy rates.…”
Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacerbate a couple's difficulty in conceiving due mainly to the metabolic influence of obesity; however, the negative impacts of low peripheral body fat, excessive exercise, the increasing prevalence of sexually transmitted diseases, and smoking all have significant negative effects on fertility. Other factors that impede conception are the perceived increasing prevalence of the polycystic ovary syndrome, which is further exacerbated by obesity, and the presence of uterine fibroids and endometriosis (a progressive pelvic inflammatory disorder) which are more prevalent in older women. A tendency for an earlier sexual debut and to have more sexual partners has led to an increase in sexually transmitted diseases. In addition, there are several genetic influences that may limit the number of oocytes within the ovary; consequently, by postponing attempts at childbearing, a limitation of oocyte number may become evident, whereas in previous generations with earlier conception this potentially reduced reproductive life span did not manifest in infertility. Environmental influences on reproduction are under increasing scrutiny. Although firm evidence is lacking however, dioxin exposure may be linked to endometriosis, phthalate exposure may influence ovarian reserve, and bisphenol A may interfere with oocyte development and maturation. However, chemotherapy or radiotherapy is recognized to lead to ovarian damage and predispose the woman to ovarian failure.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.