Does vitamin‐deficient diet cause deafness? Results of animal experimentation

Barlow, Roy A.

doi:10.1288/00005537-192709000-00003

The Laryngoscope

1927

DOI: 10.1288/00005537-192709000-00003

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Does vitamin‐deficient diet cause deafness? Results of animal experimentation

Roy A. Barlow

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1928

1984

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Cited by 10 publications

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“…As soon as the intercellular substance calcifies, the connective-tissue "nucleus" is' completed (Plate I, 4). Even if one disregards its chemical composition and other properties, it must be recalled that one of them may be stained red with eosin (Plate 1, 2) and the other blue with alum-hematoxylin (Plate The gradual appearance of two different intercellular substances represents the first step in the development of a center for the subsequent formation of lamellar bone.…”

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CIII. Bone Pathology and its Relation to the Problem of Otosclerosis

Weber

1928

Ann Otol Rhinol Laryngol

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Research in pathology will succeed only if it is built upon a thorough knowledge of normal conditions. Normal histology is the foundation of histopathology. More particularly research in bone pathology requires a detailed knowledge of the construction of normal bone, which is the end-result of a slow and complicated process. Obviously its final formation cannot be properly interpreted without an understanding of this development. The pathologic changes in the bony system represent a repetition of the individual steps of the normal growth, or they may be enhanced by the addition of new developmental phases. Thus the contested questions of bone pathology are also those of normal bone histology.What has just been stated concerning the bony system in general is of significance to the pathology of the bony capsule of the inner ear and consequently to the problem of otosclerosis. Research into the etiology of the latter requires a knowledge of the final construction and development of the bony capsule. As far as is known this development, in all probability, follows the general principles of bone formation.

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CIII. Bone Pathology and its Relation to the Problem of Otosclerosis

Weber

1928

Ann Otol Rhinol Laryngol

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Otologic and Other Manifestations of a Diet Deficient in Vitamins: Animal Experimentation

Barlow¹

1928

Archives of Otolaryngology - Head and Neck Surgery

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Relation O Vitamns a D, B and G to Otolaryngology

Cody¹

1932

Archives of Otolaryngology - Head and Neck Surgery

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This investigation has been undertaken to determine the effect of a deficiency in vitamins A, D, B and G on the ear, nose and throat. The methods used in the study have been a comprehensive but incomplete review of the literature and animal experimentation with clinical application of the facts learned therefrom and from my practice. The literature on vitamins1 is enormous, and contains fascinating by-paths in many subjects. All of these that do not bear directly on otolaryngology have been avoided. The practical value of animal experimentation and the clinical application of the findings are mutually dependent. REVIEW O LITERATUREVitamin A.\p=m-\Adiet deficient in vitamin A produces a metaplsia 2 in the epithelium of the nasal mucosa. This change is from the cylindric to the stratified squamous cells. It begins in a group of cells deep in the epithelium, which by enlarging and fusing with other similar foci extend toward the surface. Here they undermine the normal cylindric cells that are replaced by stratified squamous epithelia of the keratinizing type. At this time, or shortly thereafter, appear the first evidences of infection. The resulting pathologic condition is primarily from a nutritional disturbance, but subsequently is modified by inflammation. This nasal metaplasia is a prototype of that occurring in the epithelium at

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Does vitamin‐deficient diet cause deafness? Results of animal experimentation

Cited by 10 publications

References 2 publications

CIII. Bone Pathology and its Relation to the Problem of Otosclerosis

CIII. Bone Pathology and its Relation to the Problem of Otosclerosis

Otologic and Other Manifestations of a Diet Deficient in Vitamins: Animal Experimentation

Relation O Vitamns a D, B and G to Otolaryngology

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