Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?

Mølgaard, Christian; Larnkjær, Anni; Cashman, KD; Lamberg‐Allardt, Christel; Jakobsen, Jette; Michaelsen, Kim F.

doi:10.1016/j.bone.2009.08.056

Cited by 75 publications

(73 citation statements)

References 45 publications

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“…The lack of a relationship was present in both white and black children despite the fact that black adolescents had lower serum 25(OH)D and higher bone turnover than whites. These findings corroborate the results of previous cross-sectional studies [8, 10] and intervention studies in adolescents using lower doses of oral vitamin D [11-13, 15] which found no relationship between serum 25(OH)D and bone turnover. Our study extends these reports by using a larger sample of healthy boys and girls, and showing that perturbing baseline serum 25(OH)D through a wide range from zero to 60 ng/ml using daily oral vitamin D 3 supplementation did not change bone turnover.…”

Section: Discussionsupporting

confidence: 91%

“…A study in adolescent Chinese girls [9] reported a negative association between serum 25(OH)D and markers of both bone formation and resorption, whereas, two studies in European children across pubertal stages [8, 10] reported lack of associations between serum 25(OH)D and markers of bone formation and resorption. Though few prospective data exist that describe the effects of increasing serum 25(OH)D on bone turnover markers during puberty in healthy children, several studies [11-13] have shown that vitamin D supplementation in children increases serum 25(OH)D, but has little influence on bone turnover markers. These studies, however, used relatively low doses of vitamin D supplementation (200 – 600 IU/d) with result that the magnitude of change in serum 25(OH)D may not have been great enough to elicit measurable changes in bone turnover.…”

Section: Introductionmentioning

confidence: 99%

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Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children

Hill

Laing

Hausman

et al. 2012

Bone

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Low serum 25-hydroxyvitamin D [25(OH)D] is common in healthy children particularly in blacks. However, serum 25(OH)D concentrations for optimal bone turnover in children is unknown and few data exist that describe effects of increasing serum 25(OH)D on bone turnover markers during puberty. The purpose of this study was to determine the relationships between serum 25(OH)D and changes in serum 25(OH)D and bone turnover in white and black pubertal adolescents. Bone turnover markers were measured in 318 healthy boys and girls from Georgia (34°N) and Indiana (40°N) who participated in a study of oral vitamin D3 supplementation (0 to 4000 IU/d). Serum 25(OH)D, osteocalcin, bone alkaline phosphatase, and urine N-telopeptide cross-links were measured at baseline and 12 weeks. Relationships among baseline 25(OH)D and bone biomarkers, and between changes over 12 weeks were determined and tested for effects of race, sex, latitude, and baseline 25(OH)D. Median 25(OH)D was 27.6 ng/mL (n=318, range 10.1–46.0 ng/mL) at baseline and 34.5 ng/mL (n=302, range 9.7–95.1 ng/mL) at 12 weeks. Neither baseline nor change in 25(OH)D over 12 weeks were associated with bone turnover. The lack of association was not affected by race, sex, latitude, or baseline serum 25(OH)D. Serum 25(OH)D in the range of 10-46 ng/mL appears to be sufficient for normal bone turnover in healthy black and white pubertal adolescents.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children

Hill

Laing

Hausman

et al. 2012

Bone

View full text Add to dashboard Cite

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“…(34,35) Similarly, serum vitamin D levels were low in our study cohort and the controls, altogether 62% having values <50 nmol/L. The proportion of fracture-prone children with vitamin D deficiency (S-25OHD 37 nmol/L) was high (27%), and vitamin D levels were especially low in children with vertebral compressions.…”

Section: Discussionmentioning

confidence: 51%

Impaired bone health and asymptomatic vertebral compressions in fracture-prone children: A case-control study

Mäyränpää

Viljakainen

Toiviainen-Salo

et al. 2012

Journal of Bone and Mineral Research

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Frequent fractures in children may be a sign of impaired bone health, but it remains unestablished when and how fracture‐prone children should be assessed. This prospective study elucidated skeletal characteristics and predisposing factors in children with recurrent fractures. Findings were used to establish guidelines for screening. During a 12‐month period we recorded fracture history for all children (n = 1412) treated for an acute fracture at a large university hospital. All apparently healthy children over 4 years of age, who had sustained: (1) at least one vertebral fracture; (2) two long‐bone fractures before age 10 years; or (3) three long‐bone fractures before age 16 years, were recruited. They underwent dual‐energy X‐ray absorptiometry (DXA), laboratory tests, and spinal radiography. Information regarding family history and lifestyle factors were collected. Findings were compared with healthy controls. Sixty‐six fracture‐prone children (44 males, mean age 10.7 years; 5% of all children with fractures) were identified. Altogether, they had sustained 183 long‐bone fractures (median 3, range 0–7); 11 children had sustained vertebral fracture(s). Patients had significantly lower bone mineral density (BMD) at lumbar spine (p < 0.001), hip (p = 0.007), and whole body (p < 0.001) than the controls; only 5 children (8%) had a BMD Z‐score < −2.0. Asymptomatic vertebral compressions were prevalent, especially in those under 10 years of age. Hypercalciuria (11%) and hyperphosphaturia (22%) were significantly more prevalent than in controls. Serum concentration of 25‐hydroxyvitamin D (S‐25OHD) was below 50 nmol/L in 55%; low levels were associated with low BMD and vertebral compressions. The fracture‐prone children had lower calcium intake, less physical activity, and more often had siblings with fractures than the controls. The findings suggest that a thorough pediatric evaluation, including DXA and spinal radiography, is often indicated already after a second significant low‐energy fracture in children, in order to detect potentially preventable adverse lifestyle factors and nutritional deficits and to identify those with compromised overall bone health. © 2012 American Society for Bone and Mineral Research.

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“…For reasons still not known, African American females tend to achieve higher PBM than Caucasian females [16]. These differences in bone density are seen even during childhood and adolescence.…”

Section: Peak Bone Massmentioning

confidence: 93%

Hypoestrogenism in young women and its influence on bone mass density

Męczekalski

Podfigurna-Stopa

Genazzani

2010

Gynecological Endocrinology

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One of the most important hormonal factors responsible for bone health is estradiol. Genetic factors, adequacy of hormonal functioning, nutrition and physical activity may be the markers of bone status and development in young women. During adolescence, women reach peak bone acquisition and develop a skeletal mass. This process is largely regulated by endocrine factors mainly such as adequate levels of gonadal, adrenal and pituitary hormones. The crucial role played by estradiol and its impact on bones are very multiple. Estradiol induces growth factors' activation, receptor activator of nuclear factor kappa B ligand (RANKL) production inhibition and is mainly referred to antiresorptive activity. Clinical situations leading to hypoestrogenism has been linked to decreased bone mineral density leading to osteopenia and osteoporosis. This status both in fertile and perimenopausal women can increase the risk of pathological fractures. Such conditions as hypothalamic-pituitary insufficiency (functional hypothalamic amenorrhea, anorexia nervosa, Kallmann syndrome, hyperprolactinemia), ovarian failure (gonadal dysgenesis, premature ovarian failure) and iatrogenic treatment (surgery, chemotherapy, radiotherapy) can cause hypoestrogenism. The treatment of osteopenia and osteoporosis caused by hypoestrogenism is very essential and multidirectional. The crucial role of the therapy is the achievement of proper serum estradiol concentration and eliminate the causes of hypoestrogenism.

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Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?

Cited by 75 publications

References 45 publications

Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children

Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children

Impaired bone health and asymptomatic vertebral compressions in fracture-prone children: A case-control study

Hypoestrogenism in young women and its influence on bone mass density

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