Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study

Abstract

Objective Evaluation of vitamin D supplementation on ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency. Methods The study is a before-and-after intervention study that was performed on women with diminished ovarian reserve referred to Shahid Mofteh Clinic in Yasuj, Iran. Eligible women were prescribed vitamin D tablets at a dose of 50,000 units weekly for up to 3 months. Serum levels of vitamin D and AMH were evaluated at the end of 3 months. Significance level was also considered P ≤ 0.05. Results Our results have been showed there was a statistically significant difference in vitamin D levels of participants before [12.1(6.5)] and after [26(9.15)] the intervention (P < 0.001). Moreover, there was a statistically significant difference in serum AMH levels of participants before [0.50(0.44)] and after [0.79(0.15)] the intervention (P=0.02 ). Conclusion In conclusion, the results of the current study support a possible favorable effect of vitamin D on increase AMH expression by acting on the AMH gene promoter. Therefore, it is possible that vitamin D increases AMH levels without changing the antral follicle count/ovarian reserve.

Vitamin D Supplementation in women with Diminished Ovarian Reserve: A Randomized Controlled Trial

“…Aramesh et al did a before-and-after intervention study on 51 women with DOR (AMH <1 ng/ml) and vit D deficiency (Vit D less than 20 ng/ml) without any control group. 13 The study showed that serum levels of both AMH and Vit D increased significantly (p<0.05) after an oral dose of vitamin D 50,000 IU per week for 3 months. Before the treatment the median serum vitamin D level was 12.1 ng/ml and after the treatment it increased to 26 ng/mL which was statistically significant (p<0.001).…”

“…Our women were in their thirties on average comparable to the studies on women with DOR. 9,13,14 Middle and higher socioeconomic status and urban living provide easier access to health care as well as better control over reproductive health in comparison to people living in lower socioeconomic condition or rural areas. In this study, maximum participants had household monthly income over 10,000 taka per month.…”

“…15 The intervention arm of our study included only 24 women, a sample size much smaller than Aramesh et al (n=51) and Bacanakgil et al (n=62). 13,14 The study was a randomized controlled trial to assess the effect of vitamin D on women with low AMH. The trial had additional incidental findings about the more clinically relevant outcome, pregnancy.…”

Correlation between 25-hydroxy vitamin D levels in women and in vitro fertilization outcomes: A cross-sectional study

“…Moridi's study concluded that there is no correlation in most studies between blood levels of vitamin D and AMH. On the other hand, the study of Aramesh et al in Iran [ 43 ] found an important correlation between the number of eggs and the administration of vitamin D supplementation, which supported the possibility of the effect of vitamin D on increasing the expression of AMH through the effect of a promoter in the AMH gene, which led them to deduce that levels of AMH may be increased by vitamin D without affecting the number of follicles (and this is consistent with our result for follicles number). Other research has linked decreased vitamin D status with increased AMH levels, which causes an increase in large follicles production and the number of eggs.…”

Proteomic Analysis of Human Follicular Fluid Reveals the Pharmacological Mechanisms of the Chinese Patent Drug Kunling Pill for Improving Diminished Ovarian Reserve

“…in Chinese, not shown) [ 1 , 2 ]. The main reasons for DOR include genetics, aging, stress, endometriosis, reproductive endocrine disorders, chemotherapy and radiotherapy, excessive drinking, autoimmune diseases, chemical toxins, ovarian induction agents, certain systemic diseases, previous mumps infection, and some unclear etiologies [ 3 ]. Although there is no generally accepted definition of DOR, it has been described as a pathophysiological ovarian state characterized by poor fertility outcome, poor ovarian response, and an abnormal ovarian reserve [ 4 , 5 ].…”