Does vitamin D deficiency influence the incidence and progression of knee osteoarthritis? – A literature review

Vaishya, Raju; Vijay, Vipul; Lama, P.; Agarwal, Amit Kumar

doi:10.1016/j.jcot.2018.05.012

Cited by 28 publications

(30 citation statements)

References 30 publications

(55 reference statements)

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“…Many observational and longitudinal studies across the world reported a higher prevalence of KOA and increased risk of disease progression in vitamin D deficient patients[ 5 - 13 ]. However, few studies contradicted this association[ 14 - 20 ]. A recent review by Vaishya et al[ 20 ] reported that there was moderate evidence of a positive association between VDD and progression of radiographic OA (ROA).…”

Section: Introductionmentioning

confidence: 99%

“…However, few studies contradicted this association[ 14 - 20 ]. A recent review by Vaishya et al[ 20 ] reported that there was moderate evidence of a positive association between VDD and progression of radiographic OA (ROA). They reported limited evidence for a positive correlation between VDD and cartilage volume loss.…”

Section: Introductionmentioning

confidence: 99%

“…They reported limited evidence for a positive correlation between VDD and cartilage volume loss. There was also limited evidence of cartilage regeneration and relief of knee pain with vitamin D supplementation[ 20 ]. Most research on the progression of KOA in vitamin D deficient patients are based on older individuals[ 20 - 22 ], and no study has evaluated the association of vitamin D deficiency in younger KOA patients.…”

Section: Introductionmentioning

confidence: 99%

“…There was also limited evidence of cartilage regeneration and relief of knee pain with vitamin D supplementation[ 20 ]. Most research on the progression of KOA in vitamin D deficient patients are based on older individuals[ 20 - 22 ], and no study has evaluated the association of vitamin D deficiency in younger KOA patients. Heidari et al[ 14 ] observed significant vitamin D deficiency among young KOA patients who were below 60 years of age, but they could not notice this association in elderly patients.…”

Section: Introductionmentioning

confidence: 99%

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Association of vitamin D and knee osteoarthritis in younger individuals

Trıpathy

Gantaguru

Nanda

et al. 2020

WJO

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BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals. The increasing prevalence of obesity, sedentary lifestyle, sporting activity, and vitamin D deficiency (VDD) has been hypothesized for this shifting disease trend. This study was designed to look for the association of serum vitamin D among these young arthritic patients. AIM To look for the association of serum vitamin D in younger knee osteoarthritis (KOA) patients. METHODS In a 2-year observational study, 146 non-obese KOA patients of 35-60 years were evaluated clinically (Knee injury and Osteoarthritis Outcome Score, KOOS) and radiologically (Kellegren-Lawrence stage, KL). The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated. RESULTS Both the groups were comparable in terms of age and sex. The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL, respectively ( P < 0.001). Inadequate serum 25(OH)D level (< 30 ng/mL) was found in 46.57% of KOA patients and 24% of normal healthy participants indicating a significant positive association (odds ratio 2.77, 95%CI: 1.67-4.54, P < 0.001). The 25(OH)D level in KL grade I, II, III and IV was 43.40, 30.59, 31.56 and 33.93 ng/mL respectively (no difference, P = 0.47). Similarly, the KOOS score in sufficient, insufficient and deficient groups were 65.31, 60.36 and 65.31, respectively (no difference, P = 0.051). CONCLUSION The serum 25(OH)D level is significantly low in younger KOA patients. However, the clinical and radiological severities have no association with serum vitamin D level.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of vitamin D and knee osteoarthritis in younger individuals

Trıpathy

Gantaguru

Nanda

et al. 2020

WJO

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“…The relationship between vitamin D and knee OA has been investigated in a recent systematic review of 11 studies, which concluded that although vitamin D deficiency is associated with knee OA, the evidence regarding this association is inconsistent [53]. The studies included in the review were largely of cohort and cross-sectional design but also included two RCTs.…”

Section: Vitamin Dmentioning

confidence: 99%

Alternative and complementary therapies in osteoarthritis and cartilage repair

et al. 2020

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Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of 'alternative' therapies. These alternative therapies may have a limited evidence base and, for this reason, are often only afforded brief reference (or completely excluded) from current OA guidelines. Thus, the aim of this review was to synthesize the current evidence regarding autologous chondrocyte implantation (ACI), mesenchymal stem cell (MSC) therapy, platelet-rich plasma (PRP), vitamin D and other alternative therapies. The majority of studies were in knee OA or chondral defects. Matrix-assisted ACI has demonstrated exceedingly limited, symptomatic improvements in the treatment of cartilage defects of the knee and is not supported for the treatment of knee OA. There is some evidence to suggest symptomatic improvement with MSC injection in knee OA, with the suggestion of minimal structural improvement demonstrated on MRI and there are positive signals that PRP may also lead to symptomatic improvement, though variation in preparation makes inter-study comparison difficult. There is variability in findings with vitamin D supplementation in OA, and the only recommendation which can be made, at this time, is for replacement when vitamin D is deplete. Other alternative therapies reviewed have some evidence (though from small, poor-quality studies) to support improvement in symptoms and again there is often a wide variation in dosage and regimens. For all these therapeutic modalities, although controlled studies have been undertaken to evaluate effectiveness in OA, these have often been of small size, limited statistical power, uncertain blindness and using various methodologies. These deficiencies must leave the question as to whether they have been validated as effective therapies in OA (or chondral defects). The conclusions of this review are that all alternative interventions definitely require clinical trials with robust methodology, to assess their efficacy and safety in the treatment of OA beyond contextual and placebo effects.

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Therapeutic and Preventive Potential of Vitamin D Supplementation in Knee Osteoarthritis

Heidari

Babaei

2019

ACR Open Rheumatology

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ObjectiveVitamin D deficiency is linked with pain, function, and radiographic progression of knee osteoarthritis (KOA), but the results of studies addressing the association and effect of vitamin D supplementation for pain, function, quality of life, radiographic disease, and progression are inconsistent. The aim of this review is to determine the therapeutic and preventive potential of vitamin D supplementation in KOA.MethodEligible pertinent English language studies published in 2000 and thereafter in Medline/PubMed, Scopus, and Google Scholar were selected by using keywords that include “knee osteoarthritis,” “vitamin D supplementation,” “pain,” “structural abnormalities,” “treatment,” and “progression.”ResultsThe results of a few studies showed a preventive potential for vitamin D in KOA, but most of the randomized clinical trials that assessed the therapeutic efficacy of vitamin D supplementation in KOA found no clear therapeutic effect, with the exception of one study that found a small but significant effect of vitamin D on pain and knee function. Nonetheless, the results of a few longitudinal studies as well as systematic reviews are promising and thus encourage further studies. Inconsistent results on the effect of vitamin D on KOA may be attributed to factors such as severity of KOA, baseline level of serum vitamin D, duration of treatment, and vitamin D dosages.ConclusionGiven the multiple skeletal and extraskeletal benefits of vitamin D supplementation in elderly people, the issue of vitamin D supplementation in KOA requires further study to elucidate the dosage and duration of treatment that provides the most effective therapeutic effect.

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Does vitamin D deficiency influence the incidence and progression of knee osteoarthritis? – A literature review

Cited by 28 publications

References 30 publications

Association of vitamin D and knee osteoarthritis in younger individuals

Association of vitamin D and knee osteoarthritis in younger individuals

Alternative and complementary therapies in osteoarthritis and cartilage repair

Therapeutic and Preventive Potential of Vitamin D Supplementation in Knee Osteoarthritis

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