Does urethral competence affect urodynamic voiding parameters in women with prolapse?

Nygaard, Ingrid; Kreder, Karl J.; Brubaker, Linda; Goode, Patricia S.; Visco, Anthony G.; Weber, Anne M.; Cundiff, Geoffrey W.; Wei, John T.

doi:10.1002/nau.20436

Cited by 10 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most cases of objective voiding dysfunction were attributed to impaired detrusor contractility. Two other reports addressed the issue of whether obstructive voiding symptoms in women with POP correlated with objective bladder outflow tract obstruction, and found no such association [15,16]. Similarly, the present study found no correlation between subjective voiding difficulty and objective urodynamic bladder outflow tract obstruction, indicating that the latter should be ruled out in all women with advanced POP, irrespective of the presence or absence of the former.…”

Section: Discussioncontrasting

confidence: 52%

Urodynamic findings in women with pelvic organ prolapse and obstructive voiding symptoms

Dain

Auslander

Rosen

et al. 2010

International Journal of Gynecology & Obstetrics

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 52%

Urodynamic findings in women with pelvic organ prolapse and obstructive voiding symptoms

Dain

Auslander

Rosen

et al. 2010

International Journal of Gynecology & Obstetrics

View full text Add to dashboard Cite

show abstract

“…We previously demonstrated a 60% rate of urinary obstruction in women with stage II-IV POP using the Blaivas-Groutz obstruction nomogram for women. 15 We found that symptoms of obstruction and retention correlated poorly with urodynamic findings of obstruction. We also found that women with prolapse and USI had the same urine flow rates as women with prolapse without USI.…”

Section: Discussionmentioning

confidence: 65%

“…Thus it is illogical to use a voiding study phase to ''triage'' the stress incontinence procedure. 15 The classic use of voiding studies to diagnose obstruction is most likely unnecessary in this group since the elevated urethral pressures caused by ''urethral kinking'' resolve with prolapse reduction and the elevated PVR nearly universally returns to the normal range. 23,24 In addition, the obstruction caused by prolapse is often temporary and resolves when the women lies down or reduces the prolapse manually.…”

Section: Discussionmentioning

confidence: 99%

The correlation of voiding variables between non‐instrumented uroflowmetery and pressure‐flow studies in women with pelvic organ prolapse

Wei¹,

Nygaard²,

Brubaker³

et al. 2008

Neurourology and Urodynamics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Scott et al found that the bladder alone was present in the 41.7% cases of ewe vaginal prolapse, the uterine horn(s) in 16.7%, and both bladder and uterus in 25% [65]. Urethral constriction or kinking was observed in vaginal prolapse involving the bladder, as is often seen in women with POP and occult stress urinary incontinence [65,81]. These results suggest a high similarity between the presentation of POP in humans and ewes [82].…”

Section: Animal Models Of Popmentioning

confidence: 99%

Animal models of female pelvic organ prolapse: lessons learned

Couri

Borazjani

Paraíso

et al. 2012

Expert Review of Obstetrics & Gynecology

View full text Add to dashboard Cite

Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has high prevalence worldwide and represents a great burden to the economy. The pathophysiology of pelvic organ prolapse is multifactorial and includes genetic predisposition, aberrant connective tissue, obesity, advancing age, vaginal delivery and other risk factors. Owing to the long course prior to patients becoming symptomatic and ethical questions surrounding human studies, animal models are necessary and useful. These models can mimic different human characteristics -histological, anatomical or hormonal, but none present all of the characteristics at the same time. Major animal models include knockout mice, rats, sheep, rabbits and nonhuman primates. In this article we discuss different animal models and their utility for investigating the natural progression of pelvic organ prolapse pathophysiology and novel treatment approaches. Keywordsaberrant connective tissue; animal model; female; mesh repair; pelvic organ prolapse; POP; vaginal delivery Pelvic organ prolapse (POP) consists of descent of the anterior, posterior or apical vaginal compartments. While not life-threatening, POP often results in a significant reduction in quality of life, including shame, embarrassment and sexual dysfunction. POP is also a significant economic burden to millions of women and the healthcare system since it is one of the major indications for benign gynecological surgery, accounting for over 225,000 inpatient procedures and costing more than US$1 billion per year in the USA alone [1].The pathophysiology of POP is still not well understood, but is known to involve genetic predisposition, aberrant connective tissue (CT) metabolism, pregnancy and hormonal effects, vaginal delivery, and other risk factors such as previous hysterectomy, obesity, advancing age and constipation [1]. POP often develops decades after the greatest risk © 2012 Expert Reviews Ltd * Author for correspondence: Tel.: + 1 216 444 1103, Fax: + 1 216 444 9198, damasem@ccf.org. Financial & competing interests disclosureThe authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. NIH Public Access Author ManuscriptExpert Rev Obstet Gynecol. Author manuscript; available in PMC 2013 March 01. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript factor, vaginal delivery, suggesting an additional impact of aging. Given the long time course and the complex and multifaceted nature of this disorder, animal models are a potentially useful way to improve our understanding of POP.Animal models are particularly appropriate for studying the natural progression of pathologies and investigating novel treatment approaches. However, the development of applicable animal models for POP is challenging since humans, as t...

show abstract

Does urethral competence affect urodynamic voiding parameters in women with prolapse?

Abstract: Women with POP have significant rates of urodynamic obstruction and retention, independent of their continence status. Symptoms of obstruction and retention correlate poorly with urodynamic findings.

Cited by 10 publications

References 16 publications

Urodynamic findings in women with pelvic organ prolapse and obstructive voiding symptoms

Urodynamic findings in women with pelvic organ prolapse and obstructive voiding symptoms

The correlation of voiding variables between non‐instrumented uroflowmetery and pressure‐flow studies in women with pelvic organ prolapse

Animal models of female pelvic organ prolapse: lessons learned

Contact Info

Product

Resources

About