A strand of the literature has shown that a depreciation of the real exchange rate contributes to poverty reduction. The current paper considers the issue in the other way around, by investigating whether poverty matters for the dynamics of real exchange rate. The analysis has been performed using a panel dataset of 106 countries over the period 1980-2017, and relied on the two-step system Generalized Methods of Moments (GMM). The findings are quite interesting. A rise in the level of poverty is associated with an appreciation of the real exchange rate over the full sample. However, countries with a high real per capita income experience a real exchange rate depreciation effect of poverty, while for countries with a relatively low real per capita income (such as poor countries), poverty is associated with an appreciation of the real exchange rate. Furthermore, poverty exerts an appreciation of the real exchange rate in countries with a low degree of trade openness (including trade policy liberalization), a low level of workers' productivity, and a high degree of export product concentration.