Does titanium in ionic form display a tissue-specific distribution?

Golasik, Magdalena; Wróbel, Paweł; Olbert, Magdalena; Nowak, Barbara; Czyzycki, Mateusz; Librowski, Tadeusz; Lankosz, M.; Piekoszewski, Wojciech

doi:10.1007/s10534-016-9930-8

Cited by 10 publications

(10 citation statements)

References 28 publications

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“…At the typical serum concentrations of Ti(IV), an antagonistic behavior toward Fe(III) would not take place because it is ~100 times less available. However, localized high concentrations of labile ‘ionic’ Ti(IV) released from implants could affect Fe accessibility in cells and tissues and be the source of some of the health problems associated with implant failure [121, 168].…”

Section: Intracellular Iron Inhibition By Ti(iv)mentioning

confidence: 99%

Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body

Saxena

Loza-Rosas

Gaur

et al. 2018

Coordination Chemistry Reviews

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Despite its natural abundance and widespread use as food, paint additive, and in bone implants, no specific biological function of titanium is known in the human body. High concentrations of Ti(IV) could result in cellular toxicity, however, the absence of Ti toxicity in the blood of patients with titanium bone implants indicates the presence of one or more biological mechanisms to mitigate toxicity. Similar to Fe(III), Ti(IV) in blood binds to the iron transport protein serum transferrin (sTf)1, which gives credence to the possibility of its cellular uptake mechanism by transferrin-directed endocytosis. However, once inside the cell, how sTf bound Ti(IV) is released into the cytoplasm, utilized, or stored remain largely unknown. To explain the molecular mechanisms involved in Ti use in cells we have drawn parallels with those for Fe(III). Based on its chemical similarities with Fe(III), we compare the biological coordination chemistry of Fe(III) and Ti(IV) and hypothesize that Ti(IV) can bind to similar intracellular biomolecules. The comparable ligand affinity profiles suggest that at high Ti(IV) concentrations, Ti(IV) could compete with Fe(III) to bind to biomolecules and would inhibit Fe bioavailability. At the typical Ti concentrations in the body, Ti might exist as a labile pool of Ti(IV) in cells, similar to Fe. Ti could exhibit different types of properties that would determine its cellular functions. We predict some of these functions to mimic those of Fe in the cell and others to be specific to Ti. Bone and cellular speciation and localization studies hint toward various intracellular targets of Ti like phosphoproteins, DNA, ribonucleotide reductase, and ferritin. However, to decipher the exact mechanisms of how Ti might mediate these roles, development of innovative and more sensitive methods are required to track this difficult to trace metal in vivo.

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Section: Intracellular Iron Inhibition By Ti(iv)mentioning

confidence: 99%

Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body

Saxena

Loza-Rosas

Gaur

et al. 2018

Coordination Chemistry Reviews

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“…Metal ions are also released by organic compounds in the absence of macrophages or wear debris [4]. The ionic titanium is typically distributed and accumulated to kidneys and liver and its localization correlates with calcium [74]. Significant cytotoxicity has been demonstrated in enterocytes and osteoblasts with titanium ions and nanoparticles in vitro [75].…”

Section: Hydroxyapatite As a Scavenger Of Metal Ionsmentioning

confidence: 99%

Hydroxyapatite as a Nanomaterial for Advanced Tissue Engineering and Drug Therapy

Tuukkanen

Nakamura

2017

CPD

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Hydroxyapatite (HAp) is a complicated ceramic material that varies between the way it appears in biological systems and how it is synthesized as various calcium phosphates. HAp varies in chemical composition of substituting atoms, crystallinity, grain size and electrical polarization. HAp can form solid to macro-, micro- and nanoporous structures. Also, particulate HAp can have highly porous structure. HAp can be used as coatings for metal implants in thicknesses from hundreds of microns down to hundreds of nanometers. Cotton wool-like HAp fibers can be electrospun compounded with polymers (or without) for tissue engineering (TE) scaffolds. This review describes the features of HAp that may be utilized further in developing novel applications. As a nanomaterial HAp has been applied for drug delivery. The adsorption of proteins and other compounds can be adjusted by modifying HAp composition, electrical polarization and wettability. Of special interest are the bisphosphonates that bind to HAp and thereby can be used to treat bone loss and also couple other drugs to the mineral. A new area for HAp constructs may appear in treating metallosis. HAp coating may function as a scavenger for the ions release from metal implants and thereby inhibit the adverse effects of the ion burden for the body. So far HAp is considered as safe biomaterial but nano HAp may insidiously possess adverse effects especially when ingested by cells and eliciting excess intracellular calcium. Thereby critical approach also for HAp biomaterials is of utmost importance.

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“…A recent review indicates that Ti(IV) distribution in the body does not alter the levels of essential metals in different tissues further supporting a nontoxic behaviour for Ti(IV) in the body. 108 This knowledge illuminates on how Ti(IV) anticancer compounds can be designed to bypass these molecular mechanisms (Fig. 9).…”

Section: Discussionmentioning

confidence: 99%

A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans

et al. 2017

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Despite the ubiquitous nature of titanium(IV) and several examples of its beneficial behavior in different organisms, the metal remains underappreciated in biology. There is little understanding of how the metal might play an important function in the human body. Nonetheless, new insight is obtained regarding the molecular mechanisms that regulate the blood speciation of the metal to maintain it in nontoxic and potentially bioavailable form for use in the body. This review surveys the literature on Ti(IV) application in prosthetics and in the development of anticancer therapeutics to gain insight into soluble Ti(IV) influx in the body and its long-term impact. The limitation in analytical tools makes it difficult to depict the full picture of how Ti(IV) is transported and distributed throughout the body. Improved understanding of Ti function and its interaction with biomolecules will be helpful in developing future technologies for its imaging in the body.

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Does titanium in ionic form display a tissue-specific distribution?

Cited by 10 publications

References 28 publications

Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body

Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body

Hydroxyapatite as a Nanomaterial for Advanced Tissue Engineering and Drug Therapy

A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans

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