Does time difference of the acetylcholinesterase (AChE) inhibition in different tissues exist? A case study of zebra fish (Danio rerio) exposed to cadmium chloride and deltamethrin

Zhang, Tingting; Yang, Meiyi; Pan, Hongwei; Li, Shangge; Ren, Baigang; Ren, Zongming; Xing, Na; Qi, Luhuizi; Ren, Qiang; Xu, Shiguo; Song, Jie; Ma, Jingchun

doi:10.1016/j.chemosphere.2016.10.119

Cited by 42 publications

(12 citation statements)

References 49 publications

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“…Changes of AChE enzymatic activity may alter many physiological functions in aquatic organisms, such as locomotion, predator evasion, prey location, and orientation [28]. In the present study, CuNP and the mixtures at low concentrations significantly elevated the activity of brain AChE enzyme after 2 d exposure (Fig.…”

Section: Biomarker Responsesupporting

confidence: 52%

Potential Toxicity in Crucian Carp Following Exposure to Metallic Nanoparticles of Copper, Chromium, and Their Mixtures: A Comparative Study

Liu¹,

Yan²,

Xia³

et al. 2017

Pol. J. Environ. Stud.

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Although study of the toxicity of metallic nanoparticles in aquatic organisms is increasing, there is still little known about their combined toxicity, especially in a comparative and integrated approach. The objective of this study is to compare the toxicity of copper nanoparticles (CuNP), chromium nanoparticles (CrNP), and their mixtures to crucian carp (Carassius auratus) through a comprehensive approach. A high median lethal concentration of CuNP (390.75 mg/L) and CrNP (551.03 mg/L) was calculated from the acute toxicity, indicative of low toxicity to crucian carp. After exposure for 10 d at sublethal concentrations, several biomarker responses, including the activities of brain acetylcholinesterase (AChE), gill sodium/ potassium-activated ATP (Na + /K + -ATP), liver superoxide dismutase (SOD), and catalase (CAT) were significantly inhibited by all nanoparticles in most cases, implying the neurotoxicity, osmoregulatory toxicity, and oxidative damage of metallic nanoparticles. Thereafter, the integrated biomarker response version 2 (IBRv2) integrating all biomarker responses was applied to compare the toxicity, and therefore the toxicity order was tentatively proposed as: the mixtures ≈ CuNP＞CrNP, suggesting a synergistic effect in the mixtures. The findings will help to understand the ecological impacts of metallic nanoparticles in an aquatic environment in a more complete and accurate picture.

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Section: Biomarker Responsesupporting

confidence: 52%

Potential Toxicity in Crucian Carp Following Exposure to Metallic Nanoparticles of Copper, Chromium, and Their Mixtures: A Comparative Study

Liu¹,

Yan²,

Xia³

et al. 2017

Pol. J. Environ. Stud.

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“…Thus, Cd reached the brain and caused neurotoxicity through disruption of cholinergic neurotransmission. Because in teleost fish cholinergic synapses exist both in the brain and muscles, AChE inhibition may cause a wide range of adverse effects, such as visual difficulties, cognitive impairment, deficient movement coordination, swimming, and other behavioral alterations [20,41,46,47,88]. The integrity of the mentioned functions are crucial for the survival of visual predator fish, such as P. microps , because they need to locate potential preys at distance, to recognize and discriminate adequate prey from other organisms and particles, to pursue and capture them rapidly [64].…”

Section: Resultsmentioning

confidence: 99%

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment

Miranda

Vieira

Guilhermino

2019

IJERPH

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Microplastics (MPs) were found to modulate the toxicity of other pollutants but the knowledge on the topic is still limited. The goals of this study were to investigate the short-term toxicity of cadmium (Cd) to wild Pomatochistus microps juveniles, the potential modulation of acute Cd toxicity by 1–5 µm polyethylene MPs in this species, and possible differences of sensitivity to Cd and MPs-Cd mixtures between juveniles from two distinct wild populations. Juveniles were collected in the estuaries of Minho (M-est) and Lima (L-est) Rivers (NW Portugal). One 96 h bioassay with M-est juveniles and another one with L-est juveniles were carried out in laboratory conditions. Each bioassay had 12 treatments: control, 5 Cd concentrations, 1 MPs concentration, and 5 MPs-Cd mixtures. No significant differences in Cd-induced mortality between juveniles from distinct estuaries or between juveniles exposed to Cd alone and those exposed to MPs-Cd mixtures were found. The total 96h LC10 and LC50 of Cd alone were 2 mg/L (95% CI: 0–4 mg/L) and 8 mg/L (95% CI: 2–17 mg/L), respectively. Cd alone significantly decreased the post-exposure predatory performance (PEPP) of M-est (≥6 mg/L) and L-est juveniles (≥3 mg/L), and acetylcholinesterase (AChE) activity of M-est juveniles (13 mg/L). MPs alone (0.14 mg/L) significantly reduced the PEPP and AChE activity of L-est juveniles but not of M-est juveniles. MPs-Cd mixtures (3–13 mg/L of Cd + 0.14 mg/L of MPs) significantly inhibited the PEPP of juveniles from both estuaries and AChE of L-est estuary juveniles but not of M-est juveniles. Evidences of toxicological interactions, namely antagonism, between MPs and Cd were found. Overall, the results indicate that MPs modulated the sub-lethal toxic effects of Cd in wild P. microps juveniles, especially neurotoxicity. Moreover, the environmental conditions of the natural habitats to which juveniles were exposed during pre-developmental phases influence the sub-lethal toxicity of Cd, MPs, and their mixtures. The implications to environmental and human risk assessment are discussed and further research is needed.

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“…For example, Pb exposure results in anemia and an impact on hemoglobin synthesis [ 8 , 10 ]. Cd exposure is related to nephropathy, lung cancer, osteoporosis, abnormal hemopoiesis, and various others [ 11 – 13 ]. The essential metals in excess levels are also toxic to organisms [ 14 , 15 ]; for example, a high level of Cu influences erythrocyte function [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Metals in Fishes from Yongshu Island, Southern South China Sea: Human Health Risk Assessment

Cai

et al. 2017

Journal of Toxicology

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In order to assess the bioaccumulation of metals associated with gender, tissues, and their potential ecological risk, four species of fish were collected from the Yongshu Island in the Southern South China Sea. Metals and stable Pb isotopes in their tissues (muscle, gill, liver, intestine, and ovary) were determined. The concentrations of metals (mg/kg, dry weight) in these species were ND–21.60 (Cd), 1.21–4.87 (Cr), 0.42–22.4 (Cu), 1.01–51.8 (Mn), 0.30–3.28 (Ni), 6.04–1.29 × 103 (Zn), 14.89–1.40 × 103 (Fe), and 0.22–3.36 (Pb). In general, the liver and intestine absorbed more metals than the other tissues. Metals accumulation can be influenced by gender and feeding behavior and in fact, female fish and dietary exposure are more prone to accumulate metals. In addition, Pb isotopic ratios indicated that all species had significant biological fractionation, which may not make them good tracers for source identification. The metal concentrations of most samples were lower than the national standard values of the FAO (USA), which suggested that human consumption of these species may not cause health risks. However, since the surrounding areas are developing rapidly, the potential environmental risk of metals will intensify and should receive more attention.

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Does time difference of the acetylcholinesterase (AChE) inhibition in different tissues exist? A case study of zebra fish (Danio rerio) exposed to cadmium chloride and deltamethrin

Cited by 42 publications

References 49 publications

Potential Toxicity in Crucian Carp Following Exposure to Metallic Nanoparticles of Copper, Chromium, and Their Mixtures: A Comparative Study

Potential Toxicity in Crucian Carp Following Exposure to Metallic Nanoparticles of Copper, Chromium, and Their Mixtures: A Comparative Study

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment

Metals in Fishes from Yongshu Island, Southern South China Sea: Human Health Risk Assessment

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