Does thyroid autoimmunity affect the reproductive outcome in women with thyroid autoimmunity undergoing assisted reproductive technology?

Abstract

Problem: Our study aims to investigate whether the anti-thyroperoxidase antibody (TPO-Ab) and TSH level in euthyroid women have any association with reproductive outcomes after the ART cycle. Methods of study: A total of 1107 patients who were enrolled in the study were divided into four groups based on serum TSH level and TPO-Ab status: group A,

The effects of metabolic indicators and immune biomarkers on pregnancy outcomes in women with recurrent spontaneous abortion: a retrospective study

“…Some studies have reported no discernible association between the presence of TPO-Ab and rates of miscarriage or successful deliveries ( 29 , 30 ). In contrast, others reported higher rates of miscarriage and lower delivery rates in TPO-Ab-positive patients compared to negative patients due to shifts in metabolic and immune status ( 31 – 33 ). Vitamin D deficiency is considered a trigger for autoimmune diseases and is decreased in patients with autoimmune thyroid diseases.…”

High level of thyroid peroxidase antibodies as a detrimental risk of pregnancy outcomes in euthyroid women undergoing ART: A meta‐analysis

“…Some studies found that the presence of TPO‐Ab was not associated with pregnancy loss or delivery rate (DR) (Litwicka et al, 2015; Plowden et al, 2016; Unuane et al, 2017). By contrast, others reported that TPO‐Ab positive patients showed higher miscarriage rat (MR) and lower DR than negative patients (Seungdamrong et al., 2017; He et al, 2020; Zhong et al, 2012). A previous meta‐analysis involving 14 literatures showed that TAI had no significant adverse effect on the ART outcomes, including clinical pregnancy rate, biochemical pregnancy rate, MR, DR and the number of oocytes retrieved (Venables et al, 2020).…”

“…T A B L E 1 Summary of characteristics of the included studies. He et al, 2020;Kutteh et al, 1999;Muller et al, 1999); TG-Ab included as indicator of TAI in 6 articles (Karacan et al, 2013;Kilic et al, 2008;Liu et al, 2020;Mintziori et al, 2014;Sakar et al, 2016;Tan et al, 2014). Finally, 7 papers published from 2003 to 2020, were included for our meta-analysis (Figure 1) (Chen et al, 2017;Łukaszuk et al, 2015;Negro et al, 2005Negro et al, , 2007Poppe et al, 2003;Unuane et al, 2016Unuane et al, , 2017.…”

“…Some studies found that the presence of TPO-Ab was not associated with pregnancy loss or delivery rate (DR) (Litwicka et al, 2015;Plowden et al, 2016;Unuane et al, 2017). By contrast, others reported that TPO-Ab positive patients showed higher miscarriage rat (MR) and lower DR than negative patients (Seungdamrong et al, 2017;He et al, 2020;Zhong et al, 2012).…”

“…After detailed evaluation of the remaining 27 articles, 6 studies were excluded because 2 articles involved people either with apparent hypothyroidism (Poppe et al, 2020) or with recurrent miscarriages (Bliddal et al, 2019); 4 studies without the criteria defining the positivity of TAI (Cai et al, 2019; Pekcan et al, 2019; Wang et al, 2017; Weghofer et al, 2016). As we defined TPO‐Ab concentration >34 IU/mL or >100 IU/mL as threshold, 16 articles were excluded with: TPO‐Ab threshold below 34 IU/mL in 6 articles (Andrisani et al, 2018; Caccavo et al, 2016; Chai et al, 2014; Litwicka et al, 2015; Medenica et al, 2018; Zhong et al, 2012); TPO‐Ab threshold between 34 IU/mL and 100 IU/mL in 4 articles (Devi et al, 2019; He et al, 2020; Kutteh et al, 1999; Muller et al, 1999); TG‐Ab included as indicator of TAI in 6 articles (Karacan et al, 2013; Kilic et al, 2008; Liu et al, 2020; Mintziori et al, 2014; Sakar et al, 2016; Tan et al, 2014). Finally, 7 papers published from 2003 to 2020, were included for our meta‐analysis (Figure 1) (Chen et al, 2017; Łukaszuk et al, 2015; Negro et al, 2005, 2007; Poppe et al, 2003; Unuane et al, 2016, 2017).…”