Does the Use of Surgical Adjuncts Affect Postoperative Infection Rates in Neuro-oncology Surgery?

Treatment of Ventriculitis and Meningitis After Neurosurgery Caused by Carbapenem-Resistant Enterobacteriaceae (CRE): A Challenging Topic

“…of Patients Infection Rate% Risk Factors Comment Corsini Campioli et al 36 5328 1.1% Emergency surgery Dirty surgery Antibiotic prophylaxis (ABP) Cefazolin and vancomycin for ABP Jiménez-Martínez et al 37 595 15.3% ASA a score > 2 Extrinsic tumors Re-intervention IRF b ASA score > 2 Re-intervention Chen et al 18 755 8.60% Male patients GCS c under 12 External ventricular drainage Lumbar drainage Enteral nutrition Surgery duration > 4.5 hours Repeat operations Antibiotic prophylaxis Concurrent infection IRF Diabetes mellitus External ventricular drainage Lumbar drainage Wang et al 38 2174 9.0% Male patients Age≤45 Hypertension Tumor surgery Surgery in autumn (compared with spring) Surgical duration ≥4 hr Blood loss≥400 mL Postoperative oral infection Coma Serum RBC > normal value Trauma surgery is an independent protective factor Kuwano et al 39 1012 3.1% Three or more surgeries Radiation therapy NS d : intraoperative MRI e IRF: Three or more surgeries Only for glioma surgery. Maye et al 40 267 4.5% – NS: Intraoperative monitoring and 5-ALA f Only for neuro-oncology surgery. Caruso et al 41 71 4.2% ...…”

“…The risk factors for postoperative infection include the length of operation, reoperation, external drainage and other risk factors. 18,[36][37][38][39][40][41][42][43][44] We have also summarized the literature in recent years in Table 2. Among these postoperative infections, we found that the proportion of gram-negative bacilli is increasing, and there are increasingly more reports of Enterobacteriaceae ventriculitis and meningitis.…”