Does the Use of Nizatidine, as a Pro-kinetic Agent, Improve Gastric Emptying in Patients Post-oesophagectomy?

Abstract

Impaired gastric emptying post-surgery causes a change in eating habits. Patients in this study did not lose a significant amount of weight despite all indicating worse eating comfort. Patients required more regular meals or snacks throughout the day and avoid foods that are difficult to swallow. It is likely that gastric motility only plays a small role in the emptying process and gravity combined with appropriate drainage procedures (pyloroplasty/pyloromyotomy) at the time of surgery are more important.

Pharmacotherapy of gastroparesis

“…However, in recent clinical trials nizatidine does not seem to affect gastric empyting in post-esophagectomy delayed gastric emptying [117] and patients with functional dyspepsia [118] . There is evidence in the abstract form (McCallum RW et al [119] ) that nizatidine enhances gastric emptying in gastroesophageal reflux patients when given before bed and could augment proton pump inhibitor therapy.…”