Does the type of culture medium used influence birthweight of children born after IVF?

Zandstra, Heleen; Montfoort, Aafke P.A. van; Dumoulin, J.C.M.

doi:10.1093/humrep/dev215

Cited by 26 publications

(20 citation statements)

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“…Interestingly, regarding embryo culture conditions, the animal results point to different impacts depending on the composition of the culture media. Such differences have also been observed in human where differences between culture media have been reported by several groups focusing either on gene expression at the blastocyst stage (Kleijkers et al, ; Mantikou et al, ), or on growth trajectories—for review see Zandstra, Van Montfoort, and Dumoulin (). Especially comparison of two culture media showed differences in fetal growth trajectory as early as the second trimester of pregnancy (Nelissen, Van Montfoort, et al ), birth weight (Dumoulin et al, ), and higher post‐natal weight during the first 2 years of life (Kleijkers et al, ).…”

Section: Discussion: Validity For Human Artmentioning

confidence: 72%

“…The placenta controls fetal development and growth through the transport of gases, nutrients and waste between dam and fetus, but also through its intense endocrine activity (Cross, 2016 (Constancia et al, 2005(Constancia et al, , 2002 Sferruzzi-Perri, Sandovici, Constancia, & Fowden, 2017). As shown above in the case of ART procedures in various species, increased placental growth appears to be one compensatory mechanism for reduced expression of genes involved in placental transfers (Bloise et al, 2012;Delle Piane et al, 2010;Miles et al, 2004 (Kleijkers et al, 2015;Mantikou et al, 2016), or on growth trajectories-for review see Zandstra, Van Montfoort, and Dumoulin (2015). Especially comparison of two culture media showed differences in fetal growth trajectory as early as the second trimester of pregnancy , birth weight (Dumoulin et al, 2010), and higher post-natal weight during the first 2 years of life (Kleijkers et al, 2014).…”

Section: The Placenta: a Key Organ For Inducing Long Term Effectsmentioning

confidence: 99%

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Long term effects of ART: What do animals tell us?

Duranthon

Chavatte‐Palmer

2018

Molecular Reproduction Devel

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Early stages of mammalian embryonic development are now known to be very sensitive to their microenvironment, with long term effects on fetal, postnatal, and adult health, thus extending to these early stages the concept of Developmental Origin of Health and Disease (DoHaD). In this scientific context, and with 3% of births in developed countries, safety of Assisted Reproductive Techniques procedures becomes a matter of concern. Besides, embryo technologies in domestic mammals, using huge number of embryos, do not seem to evidence heavy impacts on adult phenotypes. This paper first discusses what can or cannot be concluded from farm animal data, then develops long term effects of ART procedures (ovarian stimulation, in vitro fertilization and embryo culture) evidenced in model species (mainly mouse model). Recent literature demonstrates both individual and cumulative effects of each ART procedure on fetal and postnatal phenotypes. In a second part, because they are sources for further perturbations, immediate effects of ART on early embryo phenotypes at the cellular and molecular levels are described in both farm animals and model species. Mechanistic hypotheses supporting these ART induced phenotypic alterations are subsequently considered. Finally, taking into account interspecies differences in the mechanisms likely to be involved, the relevance of results obtained in animal models for human ART are discussed.

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Section: Discussion: Validity For Human Artmentioning

confidence: 72%

Section: The Placenta: a Key Organ For Inducing Long Term Effectsmentioning

confidence: 99%

Long term effects of ART: What do animals tell us?

Duranthon

Chavatte‐Palmer

2018

Molecular Reproduction Devel

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“…Indeed, there is some evidence to suggest that the culture environment may affect embryo development, fetal growth, birthweight, and perinatal outcome [47][48][49][50][51][52][53][54][55][56], although the majority of these studies have design shortcomings and/or are limited by sample size. Importantly, follow-up of children born following embryo culture in either single or sequential media was not reported in any of the studies included in the present meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Blastocyst culture using single versus sequential media in clinical IVF: a systematic review and meta-analysis of randomized controlled trials

Sfontouris

Martins

Nastri

et al. 2016

J Assist Reprod Genet

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Purpose The purpose of this study was to undertake a review of the available evidence comparing the use of a single medium versus sequential media for embryo culture to the blastocyst stage in clinical IVF. Methods We searched the Cochrane Central, PubMed, Scopus, ClinicalTrials.gov, Current Controlled Trials and WHO International Clinical Trials Registry Platform to identify randomized controlled trials comparing single versus sequential media for blastocyst culture and ongoing pregnancy rate. Included studies randomized either oocytes/zygotes or women. Eligible oocyte/zygote studies were analyzed to assess the risk difference (RD) and 95 % confidence intervals (CI) between the two media systems; eligible woman-based studies were analyzed to assess the risk ratio (RR) and 95 % CI for clinical pregnancy rate. Results No differences were observed between single and sequential media for either ongoing pregnancy per randomized woman (relative risk (RR) = 0.9, 95 % CI = 0.7 to 1.3, two studies including 246 women, I 2 = 0 %) or clinical pregnancy per randomized woman (RR = 1.0, 95 % CI = 0.7 to 1.4, one study including 100 women); or miscarriage per clinical pregnancy: RR = 1.3, 95 % CI = 0.4 to 4.3, two studies including 246 participants, I 2 = 0 %). Single media use was associated with an increase blastocyst formation per randomized oocyte/ zygote (relative distribution (RD) = +0.06, 95 % CI = +0.01 to Declaration of Authors' Roles Conception and design (CR, LR, WPM, IAS, and NR-F); search strategy (WPM, IAS); data extraction (WPM, PAN, IGRV, CON), analysis, and interpretation (all authors); writing the article (all authors). All authors had full access to all the data in the study and approved the final manuscript.Capsule In conclusion, there is insufficient evidence to recommend either sequential or single-step media as being superior for the culture of embryos to days 5/6 blastocyst stage. +0.12, ten studies including 7455 oocytes/zygotes, I 2 = 83 %) but not top/high blastocyst formation (RD = +0.05, 95 % CI = −0.01 to +0.11, five studies including 3879 oocytes/zygotes, I 2 = 93 %). The overall quality of the evidence was very low for all these four outcomes. Electronic supplementary materialConclusions Although using a single medium for extended culture has some practical advantages and blastocyst formation rates appear to be higher, there is insufficient evidence to recommend either sequential or single-step media as being superior for the culture of embryos to days 5/6. Future studies comparing these two media systems in well-designed trials should be performed.

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“…Culture conditions are important for the outcome of assisted reproductive technologies and have an impact on pre-and postimplantation development and possibly the future health of the offspring [1,[5][6][7][8]. An inappropriate culture can lead to impaired embryo development and even recurrent implantation failure [1,9,10].…”

Section: Introductionmentioning

confidence: 99%

Effects of granulocyte-macrophage colony-stimulating factor supplementation in culture medium on embryo quality and pregnancy outcome of women aged over 35 years

Zhou

Chu

Sha

et al. 2015

J Assist Reprod Genet

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Purpose The purpose of this study is to explore whether a low concentration of granulocyte-macrophage colony-stimulating factor (GM-CSF) supplementation in culture medium is beneficial to infertile women aged over 35 years. Conclusion Although no benefit of GM-CSF on embryo quality was observed, the addition of this factor significantly decreased the occurrence of chemical pregnancy of women aged over 35 years, indicating the role of GM-CSF in improving implantation competence of embryos derived from elderly infertile women.

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Does the type of culture medium used influence birthweight of children born after IVF?

Cited by 26 publications

References 0 publications

Long term effects of ART: What do animals tell us?

Long term effects of ART: What do animals tell us?

Blastocyst culture using single versus sequential media in clinical IVF: a systematic review and meta-analysis of randomized controlled trials

Effects of granulocyte-macrophage colony-stimulating factor supplementation in culture medium on embryo quality and pregnancy outcome of women aged over 35 years

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